• Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis : results from a phase 3, randomised, double-blind withdrawal trial 

      Brunner, Hermine I.; Ruperto, Nicolino; Zuber, Zbigniew; Keane, Caroline; Harari, Olivier; Kenwright, Andrew; Lu, Peng; Cuttica, Ruben; Keltsev, Vladimir; Xavier, Ricardo Machado; Calvo, Inmaculada; Nikishina, Irina; Pérez, Nadina Eugenia Rubio; Alexeeva, Ekaterina; Chasnyk, Vyacheslav; Horneff, Gerd; Opoka-Winiarska, Violetta; Quartier-dit-Maire, Pierre; Silva, Clovis Artur Almeida da; Silverman, Earl; Spindler, Alberto; Baildam, Eileen; Gámir, María Luz; Martin, Alan D.; Rietschel, Christoph; Siri, Daniel; Smolewska, Elzbieta; Lovell, Daniel; Martini, Alberto; De Benedetti, Fabrizio (2015) [Artigo de periódico]
      Objective To evaluate the interleukin-6 receptor inhibitor tocilizumab for the treatment of patients with polyarticular-course juvenile idiopathic arthritis ( pcJIA). Methods This three-part, randomised, placebocontrolled, ...
    • Open-label phase 3 study of intravenous golimumab in patients with polyarticular juvenile idiopathic arthritis 

      Ruperto, Nicolino; Xavier, Ricardo Machado; Lovell, Daniel (2021) [Artigo de periódico]
      Objectives To assess efficacy, pharmacokinetics (PK) and safety of intravenous (i.v.) golimumab in patients with polyarticular-course JIA (pc-JIA). Methods Children aged 2 to <18 years with active pc-JIA despite MTX therapy ...