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Infection in a rat model reactivates attenuated virulence after long-term axenic culture of Acanthamoeba spp

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Infection in a rat model reactivates attenuated virulence after long-term axenic culture of Acanthamoeba spp

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Título Infection in a rat model reactivates attenuated virulence after long-term axenic culture of Acanthamoeba spp
Autor Veríssimo, Carolina de Marco
Maschio, Vinicius José
Correa, Ana Paula Folmer
Brandelli, Adriano
Rott, Marilise Brittes
Abstract Prolonged culturing of many microorganisms leads to the loss of virulence and a reduction of their infective capacity. However, little is known about the changes in the pathogenic strains of Acanthamoeba after long culture periods. Our study evaluated the effect of prolonged culturing on the invasiveness of different isolates of Acanthamoeba in an in vivo rat model. ATCC strains of Acanthamoeba, isolates from the environment and clinical cases were evaluated. The in vivo model was effective in establishing the infection and differentiating the pathogenicity of the isolates and re-isolates. The amoebae cultured in the laboratory for long periods were less virulent than those that were recently isolated, confirming the importance of passing Acanthamoeba strains in animal models.
Contido em Memórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Vol. 108, n. 7 (nov. 2013), p. 832-835
Assunto Acanthamoeba
Virulência
[en] In vivo
[en] Virulence
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/100155
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