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Cell sorting based on motility differences

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Cell sorting based on motility differences

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Título Cell sorting based on motility differences
Autor Beatrici, Carine Priscila
Brunnet, Leonardo Gregory
Abstract Self-propelled particles are used to simulate cell aggregates in a model considering homogeneous adhesion forces between cells and using only motility differences as segregation drivers. The tendency of cells to follow their neighbors is also included in the formulation. Three model variants are explored, and the conditions on which motility differences may produce segregation are mapped in parameter diagrams. The evolution of the order parameter measuring cell segregation is similar to those found by models based on differential adhesion. It is also found that, considering only velocity differences, the faster cells envelope the slower ones, which is opposite to the ordering observed in early experiments by Jones and co-workers [Jones, Evans, and Lee, Exp. Cell. Res. 180, 287 (1989)].
Contido em Physical review. E, Statistical, nonlinear, and soft matter physics. Vol. 84, no. 3 (Sep. 2011), 031927, 5 p.
Assunto Adesao
Agregacao
Biofísica
Biomecânica
Transporte celular
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/101826
Arquivos Descrição Formato
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