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dc.contributor.authorJuraschek, Stephen P.pt_BR
dc.contributor.authorShantha, Ghanshyam Palamaner Subashpt_BR
dc.contributor.authorChu, Audrey Y.pt_BR
dc.contributor.authorMiller, Edgar R.pt_BR
dc.contributor.authorGuallar, Elliseopt_BR
dc.contributor.authorHoogeveen, Ron C.pt_BR
dc.contributor.authorBallantyne, Christie M.pt_BR
dc.contributor.authorBrancati, Frederick L.pt_BR
dc.contributor.authorSchmidt, Maria Inêspt_BR
dc.contributor.authorPankow, James S.pt_BR
dc.contributor.authorYoung, J. Hunterpt_BR
dc.date.accessioned2014-10-03T02:12:48Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/104136pt_BR
dc.description.abstractBackground: Oxidative capacity is decreased in type 2 diabetes. Whether decreased oxidative capacity is a cause or consequence of diabetes is unknown. Our purpose is to evaluate whether lactate, a marker of oxidative capacity, is associated with incident diabetes. Methods and Findings: We conducted a case-cohort study in the Atherosclerosis Risk in Communities (ARIC) study at year 9 of follow-up. We evaluated lactate’s association with diabetes risk factors at baseline and estimated the hazard ratio for incident diabetes by quartiles of plasma lactate in 544 incident diabetic cases and 533 non-cases. Plasma lactate showed a graded positive relationship with fasting glucose and insulin (P<0.001). The relative hazard for incident diabetes increased across lactate quartiles (P-trend ≤0.001). Following adjustment for demographic factors, medical history, physical activity, adiposity, and serum lipids, the hazard ratio in the highest quartile was 2.05 times the hazard in the lowest quartile (95% CI: 1.28, 3.28). After including fasting glucose and insulin the association became non-significant. Conclusions: Lactate, an indicator of oxidative capacity, predicts incident diabetes independent of many other risk factors and is strongly related to markers of insulin resistance. Future studies should evaluate the temporal relationship between elevated lactate and impaired fasting glucose and insulin resistance.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofPLoS ONE. San Francisco. Vol. 8, no. 1 (Jan. 2013), e55113, 7 p.pt_BR
dc.rightsOpen Accessen
dc.subjectÁcido lácticopt_BR
dc.subjectDiabetes mellituspt_BR
dc.subjectAterosclerosept_BR
dc.titleLactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000930021pt_BR
dc.type.originEstrangeiropt_BR


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