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dc.contributor.authorCichelero, Fábio Tremeapt_BR
dc.contributor.authorMartinez, Denispt_BR
dc.contributor.authorFuchs, Sandra Cristina Pereira Costapt_BR
dc.contributor.authorGus, Miguelpt_BR
dc.contributor.authorMoreira, Leila Beltramipt_BR
dc.contributor.authorFuchs, Flávio Dannipt_BR
dc.date.accessioned2014-11-15T02:15:56Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1745-6215pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/106994pt_BR
dc.description.abstractBackground: Obstructive sleep apnea (OSA) and hypertension are well-known cardiovascular risk factors. Their control could reduce the burden of heart disease across populations. Several drugs are used to control hypertension, but the only consistently effective treatment of OSA is continuous positive airway pressure. The identification of a drug capable of improving OSA and hypertension simultaneously would provide a novel approach in the treatment of both diseases. Methods/Design: This is a randomized double-blind clinical trial, comparing the use of chlorthalidone with amiloride versus amlodipine as a first drug option in patients older than 40 years of age with stage I hypertension (140 to 159/90 to 99 mmHg) and moderate OSA (15 to 30 apneas/hour of sleep). The primary outcomes are the variation of the number of apneas per hour and blood pressure measured by ambulatory blood pressure monitoring. The secondary outcomes are adverse events, somnolence scale (Epworth), ventilatory parameters and C reactive protein levels. The follow-up will last 8 weeks. There will be 29 participants per group. The project has been approved by the ethics committee of our institution. Discussion: The role of fluid retention in OSA has been known for several decades. The use of diuretics are well established in treating hypertension but have never been appropriately tested for sleep apnea. As well as testing the efficacy of these drugs, this study will help to understand the mechanisms that link hypertension and sleep apnea and their treatment.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofTrials. [London]. Vol. 15, p. 1-5 (Jan. 2, 2014)pt_BR
dc.rightsOpen Accessen
dc.subjectSleep apneaen
dc.subjectApneia obstrutiva do sonopt_BR
dc.subjectHypertensionen
dc.subjectHipertensãopt_BR
dc.subjectTreatmenten
dc.subjectDiuréticospt_BR
dc.subjectDiureticsen
dc.subjectClortalidonapt_BR
dc.subjectChlorthalidoneen
dc.subjectAmlodipinopt_BR
dc.subjectAmlodipineen
dc.titleThe effect of antihypertensive agents on sleep apnea : protocol for a randomized controlled trialpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000933563pt_BR
dc.type.originEstrangeiropt_BR


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