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Determinants of intensive insulin therapeutic regimens in patients with type 1 diabetes : data from a nationwide multicenter survey in Brazil

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Determinants of intensive insulin therapeutic regimens in patients with type 1 diabetes : data from a nationwide multicenter survey in Brazil

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Título Determinants of intensive insulin therapeutic regimens in patients with type 1 diabetes : data from a nationwide multicenter survey in Brazil
Autor Gomes, Marília de Brito
Negrato, Carlos Antônio
Cobas, Roberta Arnoldi
Tannus, Lucianne Righeti Monteiro
Gonçalves, Paolla Ribeiro
Silva, Pedro Carlos Barreto da
Carneiro, João Regis Ivar
Costa, Alessandra Saldanha Matheus Fernandes da
Dib, Sérgio Atala
Azevedo, Mirela Jobim de
Nery, Márcia
Rodacki, Melanie
Zajdenverg, Lenita
Montenegro Júnior, Renan Magalhães
Sepulveda, Janice
Calliari, Luís Eduardo Procopio
Jezini, Deborah Laredo
Braga, Neuza
Luescher, Jorge L.
Berardo, Renata Szundy
Arruda-Marques, Maria Carmo
Noronha, Renata Maria de
Della Manna, Thais
Salvodelli, Roberta
Penha, Fernanda Garcia
Foss, Milton Cesar
Foss-Freitas, Maria Cristina
Pires, Antonio Carlos
Robles, Fernando Cesar
Guedes, Maria de Lourdes da Silva
Dualib, Patricia Medici
Silva, Saulo Cavalcanti da
Sampaio, Emerson
Rea, Rosangela Roginski
Faria, Ana Cristina Ravazzani de Almeida
Tschiedel, Balduíno
Lavigne, Suzana Coelho de
Canani, Luis Henrique Santos
Coral, Marisa Helena Cesar
Pereira, Daniela Aline
Araújo, Luiz Antônio de
Tolentino, Monica
Pedrosa, Hermelinda Cordeiro
Prado, Flaviane A.
Rassi, Nelson
Araujo, Leticia B.
Fonseca, Reine Marie Chaves
Guedes, Alexis Dourado
Matos, Odelissa S.
Palma, Catia C. Sousa
Azulay, Rossana Santiago de Sousa
Forti, Adriana Costa e
Façanha, Cristina Figueiredo Sampaio
Montenegro, Ana Paula
Melo, Naira Horta
Rezende, Karla Freire
Ramos, Alberto
Felicio, João Soares
Santos, Flavia M.
Brazilian Type 1 Diabetes Study Group
Abstract Background: To evaluate the determinants of intensive insulin regimens (ITs) in patients with type 1 diabetes (T1D). Methods: This multicenter study was conducted between December 2008 and December 2010 in 28 public clinics in 20 Brazilian cities. Data were obtained from 3,591 patients (56.0% female, 57.1% Caucasian). Insulin regimens were classified as follows: group 1, conventional therapy (CT) (intermediate human insulin, one to two injections daily); group 2 (three or more insulin injections of intermediate plus regular human insulin); group 3 (three or more insulin injections of intermediate human insulin plus short-acting insulin analogues); group 4, basal-bolus (one or two insulin injections of long-acting plus short-acting insulin analogues or regular insulin); and group 5, basal-bolus with continuous subcutaneous insulin infusion (CSII). Groups 2 to 5 were considered IT groups. Results: We obtained complete data from 2,961 patients. Combined intermediate plus regular human insulin was the most used therapeutic regimen. CSII was used by 37 (1.2%) patients and IT by 2,669 (90.2%) patients. More patients on IT performed self-monitoring of blood glucose and were treated at the tertiary care level compared to CT patients (p < 0.001). The majority of patients from all groups had HbA1c levels above the target. Overweight or obesity was not associated with insulin regimen. Logistic regression analysis showed that economic status, age, ethnicity, and level of care were associated with IT (p < 0.001). Conclusions: Given the prevalence of intensive treatment for T1D in Brazil, more effective therapeutic strategies are needed for long term-health benefits.
Contido em Diabetology and metabolic syndrome. [London]. Vol. 6 (May 2014), 9 p.
Assunto Diabetes mellitus tipo 1
Insulina
[en] Brazil
[en] Chronic complications
[en] Insulin regimens
[en] Type 1 diabetes
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/107342
Arquivos Descrição Formato
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