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Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

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Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

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Título Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system
Autor Beck, Ruy Carlos Ruver
Lionzo, Maria Ismenia Zulian
Costa, Tania Maria Haas
Benvenutti, Edilson Valmir
Ré, Maria Inês
Gallas, Marcia Russman
Pohlmann, Adriana Raffin
Guterres, Silvia Stanisçuaski
Abstract This paper was devoted to studying the influence of coating material (nanocapsules or nanospheres), drug model (diclofenac, acid or salt) and method of preparation on the morphological characteristics of nanoparticle-coated microparticles. The cores of microparticles were obtained by spray drying or evaporation and the coating was applied by spray drying. SEM analyses showed nanostructures coating the surface of nanocapsule-coated microparticles and a rugged surface for nanosphere-coated microparticles. The decrease in their surface areas was controlled by the nanoparticulated system, which was not dependent on microparticle size. Optical microscopy and X-ray analyses indicated that acid diclofenac crystals were present in formulations prepared with the acid as well as in the nanocapsule-coated microparticles prepared with the salt. The control of coating is dependent on the use of nanocapsules or nanospheres and independent of either the characteristics of the drug or the method of preparing the core.
Contido em Brazilian journal of chemical engineering. São Paulo. Vol. 25, n. 2 (Apr./June 2008), p. 389-398
Assunto Difracao de raios x
Microparticulas
Nanoparticulas
Polímeros
[en] Coated microparticles
[en] Nanocapsules
[en] Nanoparticles
[en] SEM
[en] Spray drying
[en] X-ray diffraction
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/107578
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