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Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems

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Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems

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Título Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems
Autor Tebaldi, Marli Luiza
Leal, Débora Abrantes
Montoro, Sérgio Roberto
Petzhold, Cesar Liberato
Abstract Poly(2-(dimethylamino)ethylmethacrylate-b-methymethacrylate) (PDMAEMA-b-PMMA) poly(2- (dimethylamino)ethylmethacrylate-b-vinylcaprolactam-b-(2-(dimethylamino)ethyl methacrylate) (PDMAEMA-b-PVCL-b-PDMAEMA) and poly(vinylcaprolactam-b-(2-(dimethylamino) ethylmethacrylate-b-vinylcaprolactam) (PVCL-b-PDMAEMA-b-PVCL) block copolymers were obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization, and the effect of the solution pH on the particle size was investigated. In the case of PDMAEMA-b-PMMA, PDMAEMA was first synthesized using 2-cyanoprop-2-yl dithiobenzoate (CPDB) as a chain transfer agent (CTA), which was subsequently used for the RAFT polymerization of MMA. The triblock copolymers were obtained using PDMAEMA or PVCL as macro-CTAs prepared using dibenzyl trithiocarbonate (DBTTC) as a bifunctional RAFT agent. The structure and formation of the copolymers was confirmed through 1H NMR and SEC analysis. The particle size varied considerably depending on the pH of the aqueous solutions of copolymers indicating that these materials could be potential candidates for biomedical applications.
Contido em Materials research : ibero-american journal of materials. São Carlos. Vol. 17, supl. 1 (2014), p. 191-196
Assunto Copolímeros em bloco
Polimerizacao
[en] fragmentation chain transfer (RAFT) polymerization
[en] poly(dimethylaminoethyl methacrylate)
[en] poly(methylmethacrylate)
[en] poly(vinylcaprolactam)
[en] Reversible addition
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/108271
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