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dc.contributor.authorFiorini, Tiagopt_BR
dc.contributor.authorSusin, Cristianopt_BR
dc.contributor.authorRocha, José Mariano dapt_BR
dc.contributor.authorWeidlich, Patríciapt_BR
dc.contributor.authorVianna, Priscilapt_BR
dc.contributor.authorMoreira, Carlos Heitor Cunhapt_BR
dc.contributor.authorChies, Jose Artur Bogopt_BR
dc.contributor.authorRösing, Cassiano Kuchenbeckerpt_BR
dc.contributor.authorOppermann, Rui Vicentept_BR
dc.date.accessioned2014-12-25T02:10:13Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn0022-3484pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/108669pt_BR
dc.description.abstractBackground and Objective: A low-grade systemic inflammatory status originating from periodontal infection has been proposed to explain the association between periodontal disease and systemic conditions, including adverse obstetric outcomes. The aim of this study was to evaluate the effect of periodontal therapy during pregnancy on the gingival crevicular fluid and serum levels of six cytokines associated with periodontal disease and preterm birth. Material and Methods: A subsample of 60 women (18–35 years of age) up to 20 gestational weeks, previously enrolled in a larger randomized clinical trial, was recruited for the present study. Participants were randomly allocated to receive either comprehensive nonsurgical periodontal therapy before 24 gestational weeks (n = 30, test group) or only one appointment for supragingival calculus removal (n = 30, control group). Clinical data, and samples of blood and gingival crevicular fluid, were collected at baseline, at 26–28 gestational weeks and 30 d after delivery. The levels of interleukin (IL)-1b, IL-6, IL-8, IL-10, IL-12p70 and tumor necrosis factor-a were analyzed by flow cytometry. Results: After treatment, a major reduction in periodontal inflammation was observed in the test group, with bleeding on probing decreasing from 49.62% of sites to 11.66% of sites (p < 0.001). Periodontal therapy significantly reduced the levels of IL-1b and IL-8 in gingival crevicular fluid (p < 0.001). However, no significant effect of therapy was observed on serum cytokine levels. After delivery, the levels of IL-1b in the gingival crevicular fluid of the test group were significantly lower than were those in the control group (p < 0.001), but there were no significant differences between test and control groups regarding serum cytokine levels. Conclusion: Although periodontal therapy during pregnancy successfully reduced periodontal inflammation and gingival crevicular fluid cytokine levels, it did not have a significant impact on serum biomarkers.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofJournal of periodontal research. Copenhagen. Vol. 48, no. 1 (Feb. 2013), p. 126-133pt_BR
dc.rightsOpen Accessen
dc.subjectDoenças periodontaispt_BR
dc.subjectOdontologia : Na gravidezpt_BR
dc.titleEffect of nonsurgical periodontal therapy on serum and gingival crevicular fluid cytokine levels during pregnancy and postpartumpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000891914pt_BR
dc.type.originEstrangeiropt_BR


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