Mostrar registro simples

dc.contributor.authorSantos, Betânia Rodrigues dospt_BR
dc.contributor.authorMascarenhas, Luis Paulo Gomespt_BR
dc.contributor.authorSatler, Fabíolapt_BR
dc.contributor.authorBoguszewski, Margaret Cristina da Silvapt_BR
dc.contributor.authorSpritzer, Poli Marapt_BR
dc.date.accessioned2015-02-11T02:18:06Zpt_BR
dc.date.issued2012pt_BR
dc.identifier.issn1471-2431pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/109961pt_BR
dc.description.abstractBackground: Vitamin D deficiency has been associated with a multitude of disorders including diabetes, defective insulin secretion as well as rickets and poor bone health. Vitamin D is also a concern during childhood and adolescence and has been reported in girls from South Brazil. We determined the prevalence of vitamin D deficiency in girls from South Brazil and investigated whether the genotypic distribution of the BsmI, ApaI and TaqI polymorphisms of the VDR gene and their haplotypes were associated with vitamin D levels. Methods: Cross-sectional study including 234 apparently healthy girls aged 7 to 18 years. Height and weight were measured for calculation of body mass index (BMI) percentiles for age. Plasma levels of 25-hydroxyvitamin D [25(OH)D] were assessed. Participants were genotyped for ApaI (rs7975232), TaqI (rs731236), and BsmI (rs1544410) SNPs. Results: The median and interquartile range (25-75%) of BMI percentile was 62.0 (33.3 – 84.9). The frequency of overweight/obesity was 24.9%. Circulating levels of 25(OH)D (≥ 30 ng/mL) were adequate in 9.4%; insufficient in 54.3% (20–29 ng/mL); and deficient in 36.3% (< 20 ng/mL). Genotype frequencies were GG = 47.0%, GA = 41.5%, and AA = 11.5% for BsmI; GG = 16.7%, GT = 52.6%, and TT = 30.8% for ApaI; TT = 46.2%, TC = 44.9% and CC = 9.0% for TaqI. Genotypes with no gene variance (ancestral wild genotype) of BsmI (GG vs. GA + AA, two-tailed Student’s t-test p<0.001), ApaI (GG vs. GT + TT, two-tailed Student’s t-test p = 0.031) and TaqI (TT vs. TC + CC, two-tailed Student’s t-test p = 0.005) SNPs and the GGT haplotype (two-tailed Student’s t-test p = 0.036) were significantly associated with lower 25(OH)D levels. Conclusions: 25-hydroxyvitamin D deficiency and insufficiency were highly prevalent in this sample. The BsmI, ApaI and TaqI wild variants of the VDR gene, as well as the GGT haplotype, were associated with lower vitamin D levels, suggesting that VDR gene polymorphisms could be linked to higher susceptibility to vitamin D deficiency in a sub-population of children and adolescents.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBMC pediatrics. London. Vol. 12, no. 1 (Jun. 2012), p. 62, [14] p.pt_BR
dc.rightsOpen Accessen
dc.subject25-hydroxyvitamin Den
dc.subjectDeficiência de vitamina Dpt_BR
dc.subjectPrevalênciapt_BR
dc.subjectVDR gene polymorphismsen
dc.subjectBrasil, Região Sulpt_BR
dc.subjectPediatric female populationen
dc.titleVitamin D deficiency in girls from South Brazil : a cross-sectional study on prevalence and association with vitamin D receptor gene variantspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000852468pt_BR
dc.type.originEstrangeiropt_BR


Thumbnail
   

Este item está licenciado na Creative Commons License

Mostrar registro simples