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Association of adipokines and adhesion molecules with indicators of obesity in women undergoing mammography screening

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Association of adipokines and adhesion molecules with indicators of obesity in women undergoing mammography screening

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Título Association of adipokines and adhesion molecules with indicators of obesity in women undergoing mammography screening
Autor Souza, Caroline Isoppo de
Rosa, Daniela Dornelles
Ettrich, Betina da Gama
Cibeira, Gabriela Herrmann
Giacomazzi, Juliana
Tusset, Paloma
Prolla, Patrícia Ashton
Medeiros, Lídia Rosi de Freitas
Caleffi, Maira
Camargo Neto, Eurico
Moriguchi, Emílio Hideyuki
Graudenz, Márcia Silveira
Abstract Background: The soluble cell adhesion molecules and adipokines are elevated in patients with obesity, hypertension, type 2 diabetes mellitus, breast cancer and atherosclerosis. Objective: To investigate the relationship between anthropometric profile, dietary intake, lipid profile and fasting glycemia with serum levels of adipokines (adiponectin and PAI-1) and adhesion molecules (ICAM-1 and VCAM-1) in women without breast cancer undergoing routine mammographic screening. Design: Transversal study. Subjects: One hundred and forty-five women over 40-years old participated in this study. Results: In 39.3% of cases the BMI was above 30 kg/m2; 46.9% had hypertension, 14.5% had type 2 Diabetes Mellitus, 31.7% had dyslipidemia and 88.3% presented a waist-to-hip ratio ≥ 0.8. A linear correlation was found between serum levels of PAI-1 and triglycerides, between serum levels of PAI-1 and WHR and between serum levels of VCAM-1 and BMI. Conclusion: We found a high prevalence of obesity and metabolic syndrome. PAI-1 and VCAM-1 levels were correlated with clinical indicators of obesity and overweight.
Contido em Nutrition & metabolism. London. Vol. 9 (2012), 16 p.
Assunto Adiponectina
Inibidor 1 de ativador de plasminogênio
Molécula 1 de adesão de célula vascular
Molécula 1 de adesão intercelular
Obesidade
[en] Adiponectin
[en] Intercellular Adhesion Molecule-1
[en] Obesity
[en] Plasminogen Activator Inhibitor type-1
[en] Vascular Cell Adhesion Molecule-1
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/109963
Arquivos Descrição Formato
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