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Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies

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Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies

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Título Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
Autor Almeida, Juliana S.
Lima, Fernanda
Ros, Simoní da
Bulhões, Luis O.S.
Carvalho, Leandro Machado de
Beck, Ruy Carlos Ruver
Abstract The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 ± 2.06 and 124.17 ± 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 ± 0.6) 10-3 and (5.1 ± 0.4) 10-3 for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 ± 3.7) 10-3 min-1] and exposed solution [(40.1 ± 1.7) 10-3 min-1] as well as compared to exposed nanostructured dispersions [(19.5 ± 0.5) 10-3 and (26.6 ± 2.6) 10-3, for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutinloaded nanostructures represent alternatives to the development of innovative nanomedicines.
Contido em Nanoscale research letters. New York. Vol. 5, n. 10 (July 2010), p. 1603-1610
Assunto Atividade antioxidante
Nanocapsulas
Rutina
[en] Antioxidant activity
[en] Nanocapsules
[en] Nanoemulsions
[en] Nanoparticles
[en] Photostability
[en] Rutin
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/109964
Arquivos Descrição Formato
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