Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
dc.contributor.author | Almeida, Juliana S. | pt_BR |
dc.contributor.author | Lima, Fernanda | pt_BR |
dc.contributor.author | Ros, Simoní da | pt_BR |
dc.contributor.author | Bulhões, Luis O.S. | pt_BR |
dc.contributor.author | Carvalho, Leandro Machado de | pt_BR |
dc.contributor.author | Beck, Ruy Carlos Ruver | pt_BR |
dc.date.accessioned | 2015-02-11T02:18:08Z | pt_BR |
dc.date.issued | 2010 | pt_BR |
dc.identifier.issn | 1556-276x | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/109964 | pt_BR |
dc.description.abstract | The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 ± 2.06 and 124.17 ± 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 ± 0.6) 10-3 and (5.1 ± 0.4) 10-3 for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 ± 3.7) 10-3 min-1] and exposed solution [(40.1 ± 1.7) 10-3 min-1] as well as compared to exposed nanostructured dispersions [(19.5 ± 0.5) 10-3 and (26.6 ± 2.6) 10-3, for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutinloaded nanostructures represent alternatives to the development of innovative nanomedicines. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Nanoscale research letters. New York. Vol. 5, n. 10 (July 2010), p. 1603-1610 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Antioxidant activity | en |
dc.subject | Nanocápsulas | pt_BR |
dc.subject | Nanocapsules | en |
dc.subject | Atividade antioxidante | pt_BR |
dc.subject | Nanoemulsions | en |
dc.subject | Rutina | pt_BR |
dc.subject | Nanoparticles | en |
dc.subject | Photostability | en |
dc.subject | Rutin | en |
dc.title | Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000777855 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
Este item está licenciado na Creative Commons License
-
Artigos de Periódicos (38920)Ciências da Saúde (10529)