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Renal denervation in an animal model of diabetes and hypertension : impact on the autonomic nervous system and nephropathy

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Renal denervation in an animal model of diabetes and hypertension : impact on the autonomic nervous system and nephropathy

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Título Renal denervation in an animal model of diabetes and hypertension : impact on the autonomic nervous system and nephropathy
Autor Dias, Lucinara Dadda
Casali, Karina Rabello
Leguisamo, Natalia Motta
Azambuja, Felipe
Souza, Martina Schaan de
Okamoto, Maristela Mitiko
Machado, Ubiratan Fabres
Irigoyen, Maria Claudia Costa
Schaan, Beatriz D'Agord
Abstract Background: The effects of renal denervation on cardiovascular reflexes and markers of nephropathy in diabetichypertensive rats have not yet been explored. Methods: Aim: To evaluate the effects of renal denervation on nephropathy development mechanisms (blood pressure, cardiovascular autonomic changes, renal GLUT2) in diabetic-hypertensive rats. Forty-one male spontaneously hypertensive rats (SHR) ~250 g were injected with STZ or not; 30 days later, surgical renal denervation (RD) or sham procedure was performed; 15 days later, glycemia and albuminuria (ELISA) were evaluated. Catheters were implanted into the femoral artery to evaluate arterial pressure (AP) and heart rate variability (spectral analysis) one day later in conscious animals. Animals were killed, kidneys removed, and cortical renal GLUT2 quantified (Western blotting). Results: Higher glycemia (p < 0.05) and lower mean AP were observed in diabetics vs. nondiabetics (p < 0.05). Heart rate was higher in renal-denervated hypertensive and lower in diabetic-hypertensive rats (384.8 ± 37, 431.3 ± 36, 316.2 ± 5, 363.8 ± 12 bpm in SHR, RD-SHR, STZ-SHR and RD-STZ-SHR, respectively). Heart rate variability was higher in renal-denervated diabetic-hypertensive rats (55.75 ± 25.21, 73.40 ± 53.30, 148.4 ± 93 in RD-SHR, STZ-SHR- and RD-STZSHR, respectively, p < 0.05), as well as the LF component of AP variability (1.62 ± 0.9, 2.12 ± 0.9, 7.38 ± 6.5 in RD-SHR, STZ-SHR and RD-STZ-SHR, respectively, p < 0.05). GLUT2 renal content was higher in all groups vs. SHR. Conclusions: Renal denervation in diabetic-hypertensive rats improved previously reduced heart rate variability. The GLUT2 equally overexpressed by diabetes and renal denervation may represent a maximal derangement effect of each condition.
Contido em Cardiovascular diabetology. London. Vol. 10 (2011), 8 p.
Assunto Denervação
Diabetes mellitus
Hipertensão
Modelos animais
Nefropatias diabéticas
Rim
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/109985
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