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GLUT4 content decreases along with insulin resistance and high levels of inflammatory markers in rats with metabolic syndrome

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GLUT4 content decreases along with insulin resistance and high levels of inflammatory markers in rats with metabolic syndrome

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Título GLUT4 content decreases along with insulin resistance and high levels of inflammatory markers in rats with metabolic syndrome
Autor Leguisamo, Natalia Motta
Lehnen, Alexandre Machado
Machado, Ubiratan Fabres
Okamoto, Maristela Mitiko
Markoski, Melissa Medeiros
Pinto, Graziela Hünning
Schaan, Beatriz D'Agord
Abstract Background: Metabolic syndrome is characterized by insulin resistance, which is closely related to GLUT4 content in insulin-sensitive tissues. Thus, we evaluated the GLUT4 expression, insulin resistance and inflammation, characteristics of the metabolic syndrome, in an experimental model. Methods: Spontaneously hypertensive neonate rats (18/group) were treated with monosodium glutamate (MetS) during 9 days, and compared with Wistar-Kyoto (C) and saline-treated SHR (H). Blood pressure (BP) and lipid levels, C-reactive protein (CRP), interleukin 6 (IL-6), TNF-α and adiponectin were evaluated. GLUT4 protein was analysed in the heart, white adipose tissue and gastrocnemius. Studies were performed at 3 (3-mo), 6 (6-mo) and 9 (9-mo) months of age. Results: MetS rats were more insulin resistant (p<0.001, all ages) and had higher BP (3-mo: p<0.001, 6-mo: p = 0.001, 9-mo: p = 0.015) as compared to C. At 6 months, CRP, IL-6 and TNF-α were higher (p<0.001, all comparisons) in MetS rats vs H, but adiponectin was lower in MetS at 9 months (MetS: 32 ± 2, H: 42 ± 2, C: 45 ± 2 pg/mL; p<0.001). GLUT4 protein was reduced in MetS as compared to C rats at 3, 6 and 9-mo, respectively (Heart: 54%, 50% and 57%; Gastrocnemius: 37%, 56% and 50%; Adipose tissue: 69%, 61% and 69%). Conclusions: MSG-treated SHR presented all metabolic syndrome characteristics, as well as reduced GLUT4 content, which must play a key role in the impaired glycemic homeostasis of the metabolic syndrome.
Contido em Cardiovascular diabetology. London. Vol. 11 (2012), 10 p.
Assunto Glutamato de sódio
Hipertensão
Ratos
Transportador de glucose tipo 4
[en] Glucose transporter 4
[en] Monosodium glutamate
[en] Spontaneously hypertensive rats
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/109996
Arquivos Descrição Formato
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