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Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use

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Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use

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Título Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use
Autor Lobo, Bianca Waruar
Veiga, Venício Féo da
Cabral, Lúcio Mendes
Michel, Ricardo Cunha
Volpato, Nadia Maria
Sousa, Valéria Pereira de
Abstract Objective: The present study aimed to evaluate the influence of the relative composition of trace elements and vitamins in physicochemical stability of neonatal parenteral nutrition. Material and methods: Three formulations for neonatal administration were selected; the main variable was the presence of trace elements and vitamins. The analyses where carried out immediately after preparation and at 24 h, 48 h, 72 h and 7 days after preparation. Three methods were selected to determine globule size: light obscuration, dynamic light scattering and optical microscopy. Complementary evaluation including visual inspection, determination of pH and osmolarity, peroxide levels and measurements of zeta potential were also performed. Results: There was an observable alteration in color and phase separation in the PN stored at 25°C and 40°C. Neither globule size pattern, nor any other physicochemical characteristic evaluated appeared to be considerably altered in any of the analyzed formulations even after 7 days of storage at 5°C. Globule size in all the PN studied was consistent with the established limit, below 500 nm by DLS measurement, and PFAT5 was below 0.05% under all storage temperatures. Conclusion: Concomitant presence of trace elements and vitamins in the same neonatal formulation did not alter the evaluated aspects of stability.
Contido em Nutrition journal. London, UK. Vol. 11, n. 1 (2012), p. 26-37
Assunto Estabilidade
Nutrição parenteral
Oligoelementos
Recém-nascido
[en] Dynamic light scattering
[en] Light obscuration
[en] Lipid globules
[en] Optical microscopy
[en] Stability
[en] Total nutrient admixtures
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/110034
Arquivos Descrição Formato
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