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Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis

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Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis

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Título Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis
Autor Azúa García, Sonia Ruiz de
Matute, Carlos
Stertz, Laura
Mosquera, Fernando
Palomino, Aitor
De la Rosa, Iris
Barbeito, Sara
Vega, Patricia
Kapczinski, Flávio Pereira
González-Pinto, Ana
Abstract Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether Brain Derived Neurotrophic Factor (BDNF) levels are associated with cognitive impairment in FEP patients compared with healthy controls. Methods: 45 FEP patients and 45 healthy controls matched by age, gender and educational level were selected from the Basque Country area of Spain. Plasma BDNF levels were assessed in healthy controls and in patients. A battery of cognitive tests was applied to both groups, with the patients being assessed at 6 months after the acute episode and only in those with a clinical response to treatment. Results: Plasma BDNF levels were altered in patients compared with the control group. In FEP patients, we observed a positive association between BDNF levels at six months and five cognitive domains (learning ability, immediate and delayed memory, abstract thinking and processing speed) which persisted after controlling for medications prescribed, drug use, intelligence quotient (IQ) and negative symptoms. In the healthy control group, BDNF levels were not associated with cognitive test scores. Conclusion: Our results suggest that BDNF is associated with the cognitive impairment seen after a FEP. Further investigations of the role of this neurotrophin in the symptoms associated with psychosis onset are warranted.
Contido em BMC Psychiatry. London. Vol. 13, n. 66 2013), 27, [9] f.
Assunto Aprendizagem
Cognição
Delirium, demência, transtorno amnéstico e outros transtornos cognitivos
Fator neurotrófico derivado do encéfalo
[en] Brain-derived neurotrophic factor
[en] Cognition
[en] Psychotic disorder
[en] Schizophrenia
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/110036
Arquivos Descrição Formato
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