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Higher serum S100b and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia

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Higher serum S100b and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia

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Título Higher serum S100b and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia
Autor Zanette, Simone de Azevedo
Sarria, Jairo Alberto Dussán
Souza, Andressa de
Deitos, Alícia
Torres, Iraci Lucena da Silva
Caumo, Wolnei
Abstract Background: Fibromyalgia (FM) is conceptualized as a central sensitization (CS) condition, that presents high serum brain-derived neurotrophic factor (BDNF) and neuroglia activation. Although the S100B protein regulates neuroglia functions, it has been traditionally used as a proxy of central nervous system damage. However, neither BDNF nor S100B association with the clinical picture of FM has been elucidated. To explore their association with the pressure-pain threshold (PPT) in FM, we performed a cross-sectional study, including 56 females with confirmed FM aged 18–65 years. Linear regression models were used to adjust for potential confounding factors between serum BDNF, S100B and PPT. Results: Serum BDNF and S100B were correlated (Spearman’s Rho = 0.29). Serum BDNF (log) and S100B (log) were correlated with the PPT (log) (Partial η2 = 0.129, P = 0.012 for the BDNF (log), and Partial η2 = 0.105, P = 0.025 for the S100B (log)). Serum BDNF (log) was inversely associated with PPT (log) (β = −1.01, SE = 0.41), age (β = −0.02, SE = 0.15) and obsessive compulsive disorder (β = −0.36, SE = 0.15), while serum S100B (log) was inversely associated with PPT (log) (β = −1.38, SE = 0.50), only. Conclusions: Both neuroglia key mediators in the CS process were inversely correlated with the PPT. Serum assessment of BDNF and S100B deserve further study to determine its potential as a proxy for the CS spectrum in FM.
Contido em Molecular pain. [London]. Vol. 10 (8 Jul. 2014), p. 46, [9 p.]
Assunto Fator neurotrófico derivado do encéfalo
Fibromialgia
Limiar da dor
Proteínas S100
[en] BDNF
[en] Central sensitization
[en] Fibromyalgia
[en] Pain-pressure threshold
[en] S100B
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/110152
Arquivos Descrição Formato
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