Repositório Digital

A- A A+

Short communication : UGT1A1*28 variant allele is a predictor of severe hyperbilirubinemia in HIV-infected patients on HAART in Southern Brazil

.

Short communication : UGT1A1*28 variant allele is a predictor of severe hyperbilirubinemia in HIV-infected patients on HAART in Southern Brazil

Mostrar registro completo

Estatísticas

Título Short communication : UGT1A1*28 variant allele is a predictor of severe hyperbilirubinemia in HIV-infected patients on HAART in Southern Brazil
Autor Cason, Lisiane Turatti
Sprinz, Eduardo
Lazzaretti, Rosmeri Kuhmmer
Kuhmmer, Regina
Agnes, Grasiela
Silveira, Jussara Maria
Basso, Rossana Patricia
Pinheiro, Cezar Arthur Tavares
Silveira, Mariângela Freitas da
Almeida, Silvana de
Ribeiro, Jorge Pinto
Mattevi, Vanessa Sune
Abstract Highly active antiretroviral therapy (HAART) has increased the survival of HIV-infected patients. However, adverse effects play a major role in adherence to HAART. Some protease inhibitors (mainly atazanavir and indinavir) act as inhibitors of uridine diphosphate-glucuronosyltransferase (UGT1A1), the enzyme responsible for hepatic conjugation of bilirubin. Variations in the promoter region of the UGT1A1 gene (UGT1A1*28, rs8175347) can influence bilirubin plasma levels, modulating the susceptibility to hyperbilirubinemia. Aiming to analyze the association between UGT1A1*28 allele and hyperbilirubinemia in individuals exposed to HAART, we evaluated 375 HIV-positive individuals on antiretroviral therapy. Individuals carrying the UGT1A1*28 allele had a higher risk of developing severe hyperbilirubinemia [prevalence ratio (PR) = 2.43, 95% confidence interval (CI) 1.08–5.45, p = 0.032] as well as atazanavir users (PR = 7.72, 95% CI = 3.14–18.98, p < 0.001). This is the first description of such an association in Brazilian HIV patients, which shows that in African-American and Euroamerican HAART users, the UGT1A1*28 allele also predisposes to severe hyperbilirubinemia, especially in those exposed to atazanavir.
Contido em AIDS research and human retroviruses. New York. Vol. 28, no. 9 (Sept. 2012), p. 1015-1018
Assunto Alelos
Hiperbilirrubinemia
HIV
Terapia anti-retroviral de alta atividade
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/111605
Arquivos Descrição Formato
000865254.pdf (69.53Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.