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dc.contributor.authorBrondani, Letícia de Almeidapt_BR
dc.contributor.authorAssmann, Taís Silveirapt_BR
dc.contributor.authorSouza, Bianca Marmontel dept_BR
dc.contributor.authorBouças, Ana Paulapt_BR
dc.contributor.authorCanani, Luis Henrique Santospt_BR
dc.contributor.authorCrispim, Daisypt_BR
dc.date.accessioned2015-03-04T01:57:58Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/111612pt_BR
dc.description.abstractBackground: The relationship between uncoupling protein (UCP) 1–3 polymorphisms and susceptibility to obesity has been investigated in several genetic studies. However, the impact of these polymorphisms on obesity is still under debate, with contradictory results being reported. Until this date, no meta-analysis evaluated the association of UCP polymorphisms with body mass index (BMI) variability. Thus, this paper describe a meta-analysis conducted to evaluate if the -3826A/G (UCP1); - 866G/A, Ala55Val and Ins/Del (UCP2) and -55C/T (UCP3) polymorphisms are associated with BMI changes. Methods: A literature search was run to identify all studies that investigated associations between UCP1-3 polymorphisms and BMI. Weighted mean differences (WMD) were calculated for different inheritance models. Results: Fifty-six studies were eligible for inclusion in the meta-analysis. Meta-analysis results showed that UCP2 55Val/Val genotype was associated with increased BMI in Europeans [Random Effect Model (REM) WMD 0.81, 95% CI 0.20, 1.41]. Moreover, the UCP2 Ins allele and UCP3-55T/T genotype were associated with increased BMI in Asians [REM WMD 0.46, 95% CI 0.09, 0.83 and Fixed Effect Model (FEM) WMD 1.63, 95% CI 0.25, 3.01]. However, a decreased BMI mean was observed for the UCP2-866 A allele in Europeans under a dominant model of inheritance (REM WMD 20.18, 95% CI 20.35, 20.01). There was no significant association of the UCP1-3826A/G polymorphism with BMI mean differences. Conclusions: The meta-analysis detected a significant association between the UCP2-866G/A, Ins/Del, Ala55Val and UCP3- 55C/T polymorphisms and BMI mean differences.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofPLoS ONE. San Francisco. Vol. 9, no. 5 (May 2014), e96411, 10 p.pt_BR
dc.rightsOpen Accessen
dc.subjectPolimorfismo genéticopt_BR
dc.subjectObesidadept_BR
dc.subjectMetanálisept_BR
dc.subjectÍndice de massa corporalpt_BR
dc.titleMeta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variabilitypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000945893pt_BR
dc.type.originEstrangeiropt_BR


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