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Role of VEGF-A and its receptors in sporadic and MEN2-associated pheochromocytoma

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Role of VEGF-A and its receptors in sporadic and MEN2-associated pheochromocytoma

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Título Role of VEGF-A and its receptors in sporadic and MEN2-associated pheochromocytoma
Autor Ferreira, Carla Vaz
Siqueira, Débora Rodrigues
Romitti, Mirian
Ceolin, Lucieli
Assis Brasil, Beatriz Maria de Azevedo
Meurer, Luíse
Capp, Clarissa
Maia, Ana Luiza Silva
Abstract Pheochromocytoma (PHEO), a rare catecholamine producing tumor arising from the chromaffin cells, may occurs sporadically (76%–80%) or as part of inherited syndromes (20%–24%). Angiogenesis is a fundamental step in tumor proliferation and vascular endothelial growth factor (VEGF-A) is the most well-characterized angiogenic factor. The role of angiogenic markers in PHEO is not fully understood; investigations were therefore made to evaluate the expression of VEGF-A and its receptors in PHEO and correlate to clinical parameters. Twenty-nine samples of PHEO were evaluated for VEGF-A, VEGF receptor-1 (VEGFR-1) VEGFR-2 expression and microvessel density (MVD) by immunohistochemistry. Clinical data were reviewed in medical records. The mean age of patients was 38 ± 14 years, and 69% were woman. VEGF-A, VEGFR-1 and VEGFR-2 staining were detected in nearly all PHEO samples. No significant correlation was observed between VEGF-A, VEGFR-1, VEGFR-2 expression or MVD and age at diagnosis, tumor size or sporadic and hereditary PHEO. However, the levels of expression of these molecules were significantly higher in malignant PHEO samples (p = 0.027,p = 0.003 and p = 0.026, respectively).VEGF-A and its receptors were shown to be up-regulated in malignant PHEO, suggesting that these molecules might be considered as therapeutic targets for unresectable or metastatic tumors.
Contido em International journal of molecular sciences. Basel. Vol. 15, no. 4 (Apr. 2014), p. 5323-5336
Assunto Feocromocitoma
Neoplasia endócrina múltipla tipo 2a
Receptor 1 do fator de crescimento do endotélio vascular
Receptor 2 do fator de crescimento do endotélio vascular
[en] Microvessel density
[en] Pheocromocytoma
[en] VEGF-A
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/111627
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