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dc.contributor.authorPicon, Paulo Dornellespt_BR
dc.contributor.authorCosta, Marisa Boff dapt_BR
dc.contributor.authorPicon, Rafael da Veiga Chavespt_BR
dc.contributor.authorFendt, Lúcia Costa Cabralpt_BR
dc.contributor.authorSuksteris, Mauricio Leichterpt_BR
dc.contributor.authorSaccilotto, Indara Carmanimpt_BR
dc.contributor.authorDornelles, Alícia Dornelespt_BR
dc.contributor.authorSchmidt, Luis Felipe Carissimipt_BR
dc.date.accessioned2015-03-07T01:56:57Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1471-2334pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/111808pt_BR
dc.description.abstractBackground: The common cold and other viral airway infections are highly prevalent in the population, and their treatment often requires the use of medications for symptomatic relief. Paracetamol is as an analgesic and antipyretic; chlorphenamine is an antihistamine; and phenylephrine, a vasoconstrictor and decongestant. This randomized, double-blind, placebo-controlled trial sought to evaluate the efficacy and safety of a fixed-dose combination of paracetamol, chlorphenamine and phenylephrine in the symptomatic treatment of the common cold and flu-like syndrome in adults. Methods: This study enrolled 146 individuals aged 18 to 60 years who had moderate to severe flu-like syndrome or common cold. After clinical examination and laboratory tests, individuals were randomly assigned to receive the fixed-dose combination (73) or placebo (73), five capsules per day for 48 to 72 hours. The primary efficacy endpoint was the sum of the scores of 10 symptoms on a four-point Likert-type scale. To evaluate treatment safety, the occurrence of adverse events was also measured. Results: Mean age was 33.5 (±9.5) years in the placebo group and 33.8 (±11.5) in the treatment group. There were 55 women and 18 men in the placebo group, and 46 women and 27 men in the treatment group. Comparison of overall symptom scores in the two groups revealed a significantly greater reduction in the treatment group than in the placebo group (p = 0.015). Analysis at the first 13 dose intervals (± 66 h of treatment) showed a greater reduction of symptom scores in the treatment group than in the placebo group (p < 0.05). The number and distribution of adverse events were similar in both groups. Conclusion: A fixed-dose combination of paracetamol, chlorphenamine and phenylephrine was safe and more effective than placebo in the symptomatic treatment of the common cold or flu-like syndrome in adults.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBMC infectious diseases. London. Vol. 2013 (Nov. 2013), 8p.pt_BR
dc.rightsOpen Accessen
dc.subjectEfficacyen
dc.subjectResfriado comumpt_BR
dc.subjectAcetaminofenpt_BR
dc.subjectSafetyen
dc.subjectClorfeniraminapt_BR
dc.subjectSymptomsen
dc.subjectCommon colden
dc.subjectFenilefrinapt_BR
dc.subjectPlacebospt_BR
dc.subjectEnsaio clínico controlado aleatóriopt_BR
dc.titleSymptomatic treatment of the common cold with a fixed-dose combination of paracetamol, chlorphenamine and phenylephrine : a randomized, placebo-controlled trialpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000952920pt_BR
dc.type.originEstrangeiropt_BR


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