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Adiposity markers and risk of coronary heart disease in patients with type 2 diabetes mellitus

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Adiposity markers and risk of coronary heart disease in patients with type 2 diabetes mellitus

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Título Adiposity markers and risk of coronary heart disease in patients with type 2 diabetes mellitus
Autor Tonding, Simone Frederico
Silva, Flávia Moraes
Antonio, Juliana Peçanha
Azevedo, Mirela Jobim de
Canani, Luis Henrique Santos
Almeida, Jussara Carnevale de
Abstract Background: This cross-sectional study aimed to evaluating the association between body adiposity markers and high-risk of coronary heart disease (CHD) in patients with type 2 diabetes. Methods: Recent adiposity markers [waist-to-height ratio, conicity index (C-index) and body adiposity index] and traditional markers [BMI, waist circumference and waist-to-hip ratio (WHR)] were measured. The 10-year risk of fatal CHD was estimated according to UKPDS risk engine scores. Patients were divided into high (CHD risk ≥20%; n = 99) or low-moderate (CHD risk <20%; n = 321) risk groups. Multiple logistic regression models were performed to analyze associations between CHD risk (outcome) and adiposity markers. Results: A total of 420 patients with type 2 diabetes (61.9 ± 9.5 years; 53.5% females; HbA1c 7.6 ± 1.6%) were evaluated. The high risk group had greater proportions of elevated C-index and BMI values than patients with low-moderate risk. No between-group differences in other adiposity markers were observed. In multiple logistic regression models, only C-index values ≥1.35 were associated with CHD risk >20% (OR = 1.69; 95% CI 1.03-2.78; P = 0.039) after adjusting for confounders (sedentary lifestyle, diabetic nephropathy, serum creatinine, and diabetes duration). The association between WHR and CHD risk did not hold in this sample. Conclusions: The C-index was the body adiposity marker best associated with high risk of fatal CHD in these patients with type 2 diabetes.
Contido em Nutrition journal. London. Vol. 13 (Dec. 2014), 7p.
Assunto Antropometria
Diabetes mellitus tipo 2
Distribuição da gordura corporal
Doença das coronárias
Obesidade abdominal
[en] Anthropometry
[en] Body fat distribution
[en] Coronary disease
[en] Diabetes mellitus type 2
[en] Obesity abdominal
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/111821
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