Repositório Digital

A- A A+

Major components of metabolic syndrome and adiponectin levels : a cross-sectional study

.

Major components of metabolic syndrome and adiponectin levels : a cross-sectional study

Mostrar registro completo

Estatísticas

Título Major components of metabolic syndrome and adiponectin levels : a cross-sectional study
Autor Frankenberg, Anize Delfino von
Nascimento, Filipe Valvassori do
Gatelli, Lucas Eduardo
Nedel, Bárbara Limberger
Garcia, Sheila Piccoli
Oliveira, Carolina Soares Viana de
Rosa, Pedro Saddi
Reis, André Fernandes
Canani, Luis Henrique Santos
Gerchman, Fernando
Abstract Background: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. The purpose of the study was to investigate the relationship between adiponectin levels and MS. Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clínicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured. Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001). Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity.
Contido em Diabetology & metabolic syndrome. São Paulo. Vol. 6 (Feb. 2014), 9p.
Assunto Adiponectina
Obesidade
Síndrome X metabólica
[en] Adiponectin
[en] Metabolic syndrome
[en] Obesity
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/111826
Arquivos Descrição Formato
000953560.pdf (442.3Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.