Mostrar registro simples

dc.contributor.authorFrankenberg, Anize Delfino vonpt_BR
dc.contributor.authorNascimento, Filipe Valvassori dopt_BR
dc.contributor.authorGatelli, Lucas Eduardopt_BR
dc.contributor.authorNedel, Bárbara Limbergerpt_BR
dc.contributor.authorGarcia, Sheila Piccolipt_BR
dc.contributor.authorOliveira, Carolina Soares Viana dept_BR
dc.contributor.authorRosa, Pedro Saddipt_BR
dc.contributor.authorReis, André Fernandespt_BR
dc.contributor.authorCanani, Luis Henrique Santospt_BR
dc.contributor.authorGerchman, Fernandopt_BR
dc.date.accessioned2015-03-07T01:57:09Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1758-5996pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/111826pt_BR
dc.description.abstractBackground: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. The purpose of the study was to investigate the relationship between adiponectin levels and MS. Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clínicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured. Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001). Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofDiabetology & metabolic syndrome. São Paulo. Vol. 6 (Feb. 2014), 9p.pt_BR
dc.rightsOpen Accessen
dc.subjectAdiponectinen
dc.subjectAdiponectinapt_BR
dc.subjectSíndrome metabólicapt_BR
dc.subjectMetabolic syndromeen
dc.subjectObesidadept_BR
dc.subjectObesityen
dc.titleMajor components of metabolic syndrome and adiponectin levels : a cross-sectional studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000953560pt_BR
dc.type.originNacionalpt_BR


Thumbnail
   

Este item está licenciado na Creative Commons License

Mostrar registro simples