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Natural green coating inhibits adhesion of clinically important bacteria

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Natural green coating inhibits adhesion of clinically important bacteria

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Título Natural green coating inhibits adhesion of clinically important bacteria
Autor Trentin, Danielle da Silva
Silva, Denise Brentan
Frasson, Amanda Piccoli
Rzhepishevska, Olena
Silva, Márcia Vanusa da
Pulcini, Elinor de L.
James, Garth
Soares, Gabriel Vieira
Tasca, Tiana
Ramstedt, Madeleine
Giordani, Raquel Brandt
Lopes, Norberto Peporine
Macedo, Alexandre José
Abstract Despite many advances, biomaterial-associated infections continue to be a major clinical problem. In order to minimize bacterial adhesion, material surface modifications are currently being investigated and natural products possess large potential for the design of innovative surface coatings. We report the bioguided phytochemical investigation of Pityrocarpa moniliformis and the characterization of tannins by mass spectrometry. It was demonstrated that B-type linked proanthocyanidins-coated surfaces, here termed Green coatings, reduced Gram-positive bacterial adhesion and supported mammalian cell spreading. The proposed mechanism of bacterial attachment inhibition is based on electrostatic repulsion, high hydrophilicity and the steric hindrance provided by the coating that blocks bacterium-substratum interactions. This work shows the applicability of a prototype Green-coated surface that aims to promote necessary mammalian tissue compatibility, while reducing bacterial colonization.
Contido em Scientific reports. London. Vol. 5 (Feb. 2015), 8287, 10 p.
Assunto Biofilmes
Espectrometria de massa
Microbiologia
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/114534
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