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Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid

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Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid

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Título Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid
Autor Pereira, Gabriela Garrastazu
Dimer, Frantiescoli Anversa
Guterres, Silvia Stanisçuaski
Kechinski, Carolina Pereira
Granada, Jonas Eichelberger
Cardozo, Nilo Sérgio Medeiros
Abstract The influence of the composition and preparation method on the sol–gel transition temperature (Tsol–gel) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of Tsol–gel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the Tsol–gel values. In contrast, the addition of microparticles caused a reduction in Tsol–gel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds.
Contido em Química nova. São Paulo. Vol. 36, n. 8 (2013), p. 1121-1125
Assunto Copolímeros
Reologia
[en] Burn wounds
[en] Rheology
[en] Thermoreversible gel
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/115203
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