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Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies : analysis of the control arm of PATRICIA

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Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies : analysis of the control arm of PATRICIA

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Título Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies : analysis of the control arm of PATRICIA
Autor Castellsague, Xavier
Naud, Paulo Sergio Viero
Chow, Song-Nan
Wheeler, Cosette M.
Germar, Maria Julieta V.
Lehtinen, Matti
Paavonen, Jorma
Jaisamrarn, Unnop
Garland, Suzanne M.
Salmerón, Jorge
Apter, Dan L.
Kitchener, Henry
Teixeira, Júlio César
Skinner, S. Rachel
Limson, Genara
Szarewski, Anne
Romanowski, Barbara
Aoki, Fred Y.
Schwarz, Tino F.
Poppe, Willy A. J.
Bosch, F. Xavier
Carvalho, Newton S. de
Peters, Klaus
Tjalma, Wiebren A. A.
Safaeian, Mahboobeh
Raillard, Alice
Descamps, Dominique
Struyf, Frank
Dubin, Gary
Rosillon, Dominique
Baril, Laurence
HPV PATRICIA Study Group
Abstract Background. We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681). Methods. Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15–25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]). Results. High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lower risk of incident and persistent infection, atypical squamous cells of undetermined significance or greater (ASCUS+), and cervical intraepithelial neoplasia grades 1/2 or greater (CIN1+, CIN2+). For HPV-18, although seropositivity was associated with lower risk of ASCUS+ and CIN1+, no association between naturally acquired antibodies and infection was demonstrated. Naturally acquired HPV-16 antibody levels of 371 (95% confidence interval [CI], 242–794), 204 (95% CI, 129–480), and 480 (95% CI, 250–5756) EU/mL were associated with 90% reduction of incident infection, 6-month persistent infection, and ASCUS+, respectively. Conclusions. Naturally acquired antibodies to HPV-16, and to a lesser extent HPV-18, are associated with some reduced risk of subsequent infection and cervical abnormalities associated with the same HPV type.
Contido em The Journal of infectious diseases. Oxford. Vol. 210, no. 4 (Aug. 2014), p. 517-534
Assunto Neoplasia intra-epitelial cervical
Papillomavirus humano 16
Papillomavirus humano 18
[en] Cervical abnormality
[en] HPV
[en] Infection
[en] Naturally acquired antibodies
[en] Risk reduction
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/115351
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