Mostrar registro simples

dc.contributor.authorCastellsague, Xavierpt_BR
dc.contributor.authorNaud, Paulo Sergio Vieropt_BR
dc.contributor.authorChow, Song-Nanpt_BR
dc.contributor.authorWheeler, Cosette M.pt_BR
dc.contributor.authorGermar, Maria Julieta V.pt_BR
dc.contributor.authorLehtinen, Mattipt_BR
dc.contributor.authorPaavonen, Jormapt_BR
dc.contributor.authorJaisamrarn, Unnoppt_BR
dc.contributor.authorGarland, Suzanne M.pt_BR
dc.contributor.authorSalmerón, Jorgept_BR
dc.contributor.authorApter, Dan L.pt_BR
dc.contributor.authorKitchener, Henrypt_BR
dc.contributor.authorTeixeira, Júlio Césarpt_BR
dc.contributor.authorSkinner, S. Rachelpt_BR
dc.contributor.authorLimson, Genarapt_BR
dc.contributor.authorSzarewski, Annept_BR
dc.contributor.authorRomanowski, Barbarapt_BR
dc.contributor.authorAoki, Fred Y.pt_BR
dc.contributor.authorSchwarz, Tino F.pt_BR
dc.contributor.authorPoppe, Willy A. J.pt_BR
dc.contributor.authorBosch, F. Xavierpt_BR
dc.contributor.authorCarvalho, Newton S. dept_BR
dc.contributor.authorPeters, Klauspt_BR
dc.contributor.authorTjalma, Wiebren A. A.pt_BR
dc.contributor.authorSafaeian, Mahboobehpt_BR
dc.contributor.authorRaillard, Alicept_BR
dc.contributor.authorDescamps, Dominiquept_BR
dc.contributor.authorStruyf, Frankpt_BR
dc.contributor.authorDubin, Garypt_BR
dc.contributor.authorRosillon, Dominiquept_BR
dc.contributor.authorBaril, Laurencept_BR
dc.contributor.authorHPV PATRICIA Study Grouppt_BR
dc.date.accessioned2015-04-15T01:58:19Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn0022-1899pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/115351pt_BR
dc.description.abstractBackground. We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681). Methods. Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15–25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]). Results. High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lower risk of incident and persistent infection, atypical squamous cells of undetermined significance or greater (ASCUS+), and cervical intraepithelial neoplasia grades 1/2 or greater (CIN1+, CIN2+). For HPV-18, although seropositivity was associated with lower risk of ASCUS+ and CIN1+, no association between naturally acquired antibodies and infection was demonstrated. Naturally acquired HPV-16 antibody levels of 371 (95% confidence interval [CI], 242–794), 204 (95% CI, 129–480), and 480 (95% CI, 250–5756) EU/mL were associated with 90% reduction of incident infection, 6-month persistent infection, and ASCUS+, respectively. Conclusions. Naturally acquired antibodies to HPV-16, and to a lesser extent HPV-18, are associated with some reduced risk of subsequent infection and cervical abnormalities associated with the same HPV type.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe Journal of infectious diseases. Oxford. Vol. 210, no. 4 (Aug. 2014), p. 517-534pt_BR
dc.rightsOpen Accessen
dc.subjectHPVen
dc.subjectPapillomavirus humano 16pt_BR
dc.subjectNaturally acquired antibodiesen
dc.subjectPapillomavirus humano 18pt_BR
dc.subjectDisplasia do colo do úteropt_BR
dc.subjectInfectionen
dc.subjectCervical abnormalityen
dc.subjectRisk reductionen
dc.titleRisk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies : analysis of the control arm of PATRICIApt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000953416pt_BR
dc.type.originEstrangeiropt_BR


Thumbnail
   

Este item está licenciado na Creative Commons License

Mostrar registro simples