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Bioanalytical method for the quantification of the monastrol derivative anticancer candidate lasom 65 in pre-clinical pharmacokinetic investigations

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Bioanalytical method for the quantification of the monastrol derivative anticancer candidate lasom 65 in pre-clinical pharmacokinetic investigations

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Título Bioanalytical method for the quantification of the monastrol derivative anticancer candidate lasom 65 in pre-clinical pharmacokinetic investigations
Autor Torres, Bruna Gaelzer Silva
Uchôa, Flávia de Toni
Canto, Rômulo Faria Santos
Crestani, Allan
Eifler-Lima, Vera Lucia
Dalla Costa, Teresa Cristina Tavares
Abstract A simple HPLC/UV method was developed for the determination of the anticancer candidate LaSOM 65 in rat plasma. Samples were cleaned by protein precipitation with acetonitrile (recovery > 95%), after which they were subjected to chromatography under the isocratic elution of an acetonitrile:water (45:55, v/v) solution with detection at 303 nm. The method was linear (r2 > 0.98) over the concentration range (0.05–2 μg mL−1) with intra- and inter-day precision ranging from 9.6% to 13.6% and 4.3% to 5.4%, respectively. The accuracy of the method ranged from 85% to 113.6%, and it showed sufficient sensitivity to determine pharmacokinetic parameters of LaSOM 65 after intravenous administration to Wistar rats.
Contido em Química nova. São Paulo. Vol. 37, n. 3 (2014), p. 461-464
Assunto Antineoplásicos
Farmacocinética
Monastrol
[en] HPLC/UV
[en] LaSOM 65
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/115510
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