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Fos expression in the prefrontal cortex and mesencephalic dorsal raphe nucleus in lactating rats after social instigation

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Fos expression in the prefrontal cortex and mesencephalic dorsal raphe nucleus in lactating rats after social instigation

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Título Fos expression in the prefrontal cortex and mesencephalic dorsal raphe nucleus in lactating rats after social instigation
Autor Veiga, Caroline Perinazzo da
Winkelmann-Duarte, Elisa
Pavesi, Eloisa
Louzada, Simone Mattos
Miczek, Klaus Alexander
Lucion, Aldo Bolten
Almeida, Rosa Maria Martins de
Abstract Females are often less aggressive than males, but they exhibit high levels of agonistic behavior against an intruder in the area of the nest during lactation. This behavior is referred to as maternal aggression. In rats, maternal aggressive behavior occurs more often from postpartum day 3 (PPD 3) to PPD 12. Social instigation is an experimental protocol used to increase the levels of aggression that are typical of the species. In the present study we used social instigation to analyze the expression of a marker of neuronal activity, c-fos. Lactating rats on PPD 5, in the presence of their pups, were divided into four groups: (1) no social instigation and no aggressive behavior, (2) social instigation and no aggressive behavior, (3) no social instigation and aggressive behavior, and (4) social instigation and aggressive behavior. Sixty minutes after the aggression test we used immunohistochemistry to detect Fos in two brain regions, the ventral-orbital region of the prefrontal cortex (VO PFC) and dorsal raphe nucleus (DRN). Our results showed that rats with aggressive behavior that were provoked exhibited an increase in Fos expression in the VO PFC compared with the control group (i.e., no social instigation and no aggressive behavior). No change in Fos expression was found in the DRN. These results complement previous findings with microinjection of serotonin 5-hydroxytryptamine-1B receptor agonists into the same region, demonstrating that the VO PFC is an important region in the modulation of maternal aggressive behavior.
Contido em Psychology & neuroscience. Rio de Janeiro, RJ. Vol. 6, n. 1 (2013), 115-121.
Assunto Agressividade
Comportamento materno
Etologia animal
Proteínas proto-oncogênicas c-fos
Psicologia experimental
Ratos
[en] Dorsal raphe nucleus
[en] Fos
[en] Maternal aggression
[en] Prefrontal cortex
[en] Social instigation
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/116913
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