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dc.contributor.authorLazzaretti, Rosmeri Kuhmmerpt_BR
dc.contributor.authorGasparotto, Aline Simaspt_BR
dc.contributor.authorSassi, Marina Gomes de Moraespt_BR
dc.contributor.authorPolanczyk, Carisi Annept_BR
dc.contributor.authorKuhmmer, Reginapt_BR
dc.contributor.authorSilveira, Jussara Mariapt_BR
dc.contributor.authorBasso, Rossana Patriciapt_BR
dc.contributor.authorPinheiro, Cezar Arthur Tavarespt_BR
dc.contributor.authorSilveira, Mariângela Freitas dapt_BR
dc.contributor.authorSprinz, Eduardopt_BR
dc.contributor.authorMattevi, Vanessa Sunept_BR
dc.date.accessioned2015-05-28T01:59:13Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1537-744Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/117286pt_BR
dc.description.abstractThis study evaluated the impact of 9 single nucleotide polymorphisms (SNPs) in 6 candidate genes (APOB, APOA5, APOE, APOC3, SCAP, and LDLR) over dyslipidemia in HIV-infected patients on stable antiretroviral therapy (ART) with undetectable viral loads. Blood samples were collected from614 patients at reference services in the cities of Porto Alegre, Pelotas, and Rio Grande in Brazil. The SNPs were genotyped by conventional polymerase chain reaction (PCR) and real-time PCR. The prevalence of dyslipidemia was particularly high among the protease inhibitors-treated patients (79%). APOE (rs429358 and rs7412) genotypes and APOA5 −1131T>C (rs662799) were associated with plasma triglycerides (TG) and low-density-lipoprotein cholesterol levels (LDL-C). The APOA5 −1131T>C (rs662799) and SCAP 2386A>G (rs12487736) polymorphisms were significantly associated with high-densitylipoprotein cholesterol levels. The mean values of the total cholesterol and LDL-C levels were associated with both the APOB SP Ins/Del (rs17240441) and APOB XbaI (rs693) polymorphisms. In conclusion, our data support the importance of genetic factors in the determination of lipid levels in HIV-infected individuals. Due to the relatively high number of carriers of these risk variants, studies to verify treatment implications of genotyping before HAART initiation may be advisable to guide the selection of an appropriate antiretroviral therapy regimen.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofScientific World Journal. Newbury, Berkshire. Vol. 2013 (Sept. 2013), article ID 608415, 10 pagespt_BR
dc.rightsOpen Accessen
dc.subjectTerapia antirretroviral de alta atividadept_BR
dc.subjectDislipidemiaspt_BR
dc.subjectHIVpt_BR
dc.subjectMarcadores genéticospt_BR
dc.titleGenetic markers associated to dyslipidemia in HIV-infected individuals on HAARTpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000950237pt_BR
dc.type.originEstrangeiropt_BR


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