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Melatonin prevents hyperglycemia in a model of sleep apnea

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Melatonin prevents hyperglycemia in a model of sleep apnea

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Título Melatonin prevents hyperglycemia in a model of sleep apnea
Autor Kaminski, Renata Schenkel Rivera
Martinez, Denis
Fagundes, Micheli
Martins, Emerson Ferreira
Montanari, Carolina Caruccio
Rosa, Darlan Pase da
Fiori, Cintia Zappe
Marroni, Norma Anair Possa
Abstract Objective: Obstructive sleep apnea is a common disorder associated with aging and obesity. Apneas cause repeated arousals, intermittent hypoxia, and oxidative stress. Changes in glucolipidic profile occur in apnea patients, independently of obesity. Animal models of sleep apnea induce hyperglycemia. This study aims to evaluate the effect of the antioxidants melatonin and N-acetylcysteine on glucose, triglyceride, and cholesterol levels in animals exposed to intermittent hypoxia. Materials and methods: Two groups of Balb/c mice were exposed to intermittent hypoxia (n = 36) or sham intermittent hypoxia (n = 36) for 35 days. The intermittent hypoxia group underwent a total of 480 cycles of 30 seconds reducing the inspired oxygen fraction from 21% to 7 ± 1% followed by 30 seconds of normoxia, during 8 hours daily. Melatonin or N-acetylcysteine were injected intraperitonially daily from day 21 on. Results: At day 35, glucose levels were significantly higher in the intermittent hypoxia group than in the control group. The intermittent hypoxia groups receiving N-acetylcysteine and vehicle showed higher glucose levels than the group receiving melatonin. The lipid profile was not affected by intermittent hypoxia or antioxidant administration. Conclusions: The present results suggest that melatonin prevents the well-recognized increase in glucose levels that usually follows exposure to intermittent hypoxia. Further exploration of the role of melatonin in sleep apnea is warranted.
Contido em Archives of endocrinology and metabolism. São Paulo. Vol. 59, no. 1 (fev. 2015), p. 66-70
Assunto Hiperglicemia
Melatonina
Síndromes da apnéia do sono
[en] Glucose
[en] Intermittent hypoxia
[en] N-acetylcysteine
[en] Triglycerides
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/117947
Arquivos Descrição Formato
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