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Isolated soy protein-based diet ameliorates glycemia and antioxidants enzyme activities in streptozotocin-induced diabetes

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Isolated soy protein-based diet ameliorates glycemia and antioxidants enzyme activities in streptozotocin-induced diabetes

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Título Isolated soy protein-based diet ameliorates glycemia and antioxidants enzyme activities in streptozotocin-induced diabetes
Autor Mendes, Roberta Hack
Hagen, Martine Elisabeth Kienzle
Barp, Jaqueline
Jong, Erna Vogt de
Moreira, Julia Dubois
Oliveira, Álvaro Reischak de
Irigoyen, Maria Claudia Costa
Belló-Klein, Adriane
Abstract The objective of this study was to evaluate the changes induced by isolated soy protein (ISP)-based diet on glycemia and oxidative stress biomarkers in diabetic rats. Fifteen male Wistar rats (35 ± 4 g, aged 21 days) were assigned to three groups: Casein (C group), which received casein-based diet during experimental protocol; Diabetic treated with Casein (D + C group) that received caseinbased diet before and after diabetes induction; Diabetic treated with ISP (D + S group) that received casein-based diet before diabetes induction and after received ISP-based diet for the experimental protocol. Diabetes was induced by a single dose of streptozotocin (50 mg/kg body weight i.v.). After three weeks of dietary treatment, total nitrates, lipid peroxidation, antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) were measured in heart homogenates. ISP-based diet promoted an improvement in the glycemic levels of diabetic rats compared with casein-based diet (362 ± 25 vs 461 ± 30 mg/dL). CAT activity demonstrated a significant decrease in D + C and D + S groups. D + S group presented a significant increase in SOD and GST activities. Lipid peroxidation was not different among experimental groups. The overall results suggested the potential benefits of ISP-based diet consumption to improve the life quality of diabetic patients.
Contido em Food and Nutrition Sciences. Irvine, CA. Vol. 5, n. 21 (Nov. 2014), p. 2089-2096
Assunto Diabetes mellitus
Estresse oxidativo
Proteina de soja
Proteínas de soja
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/118219
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