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Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos

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Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos

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Título Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos
Outro título Gene geography of Chile. Regional distribution of American, European and African genetic contributions
Autor Fuentes, Macarena
Pulgar, Iván
Gallo, Carla
Bortolini, Maria Cátira
Canizales-Quinteros, Samuel
Bedoya, Gabriel
González-José, Rolando
Ruiz-Linares, Andres
Rothhammer, Francisco
Abstract Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate of American, European and African admixture of the Chilean population. Subjects and Methods: Forty single nucleotide polymorphisms (SNP´s) which exhibit substantially different frequencies between Amerindian populations (ancestryinformative markers or AIM´s), were genotyped in a sample of 923 Chilean participants to estimate individual genetic ancestry. Results: The American, European and African individual average admixture estimates for the 15 Chilean Regions were relatively homogeneous and not statistically different. However, higher American components were found in northern and southern Chile and higher European components were found in central Chile. A negative correlation between African admixture and latitude was observed. On the average, American and European genetic contributions were similar and significantly higher than the African contribution. Weighted mean American, European and African genetic contributions of 44.34% ± 3 9%, 51.85% ± 5.44% and 3.81% ± 0 .45%, were estimated. Fifty two percent of subjects harbor African genes. Individuals with Aymara and Mapuche surnames have an American admixture of 58.64% and 68.33%, respectively. Conclusions: Half of the Chilean population harbors African genes. Participants with Aymara and Mapuche surnames had a higher American genetic contribution than the general Chilean population. These results confirm the usefulness of surnames as a first approximation to determine genetic ancestry
Contido em Revista Medica de Chile. Santiago. Vol. 142, (2014), p. 281-289
Assunto Ameríndios
Chile
Genoma humano
Indios sul-americanos
[en] American native continental ancestry group
[en] Chile
[en] Indians
[en] South american
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/118734
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