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dc.contributor.authorBiolchi, Vanderleipt_BR
dc.contributor.authorSilva Neto, Brasilpt_BR
dc.contributor.authorKoff, Walter Josept_BR
dc.contributor.authorBrum, Ilma Simonipt_BR
dc.date.accessioned2015-07-11T02:00:17Zpt_BR
dc.date.issued2012pt_BR
dc.identifier.issn1677-6119pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/119119pt_BR
dc.description.abstractBenign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially infl uence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confi dence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG ≤ 21 vs. CAG > 21 and CAG ≤ 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Braziliansen
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofInternational brazilian journal of urology. Rio de Janeiro, RJ. Vol. 38, no. 3 (May/June 2012), p. 373-379pt_BR
dc.rightsOpen Accessen
dc.subjectReceptores androgênicospt_BR
dc.subjectPolimorfismo genéticopt_BR
dc.subjectHiperplasia prostáticapt_BR
dc.titleAndrogen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian populationpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000964015pt_BR
dc.type.originNacionalpt_BR


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