Repositório Digital

A- A A+

Facial asymmetry and genetic ancestry in Latin American admixed populations

.

Facial asymmetry and genetic ancestry in Latin American admixed populations

Mostrar registro completo

Estatísticas

Título Facial asymmetry and genetic ancestry in Latin American admixed populations
Autor Quinto Sanchez, Mirsha
Adhikari, Kaustubh
Acunã Alonzo, Víctor
Cintas, Célia
Cerqueira, Caio Cesar Silva de
Ramallo, Virgínia
Castillo, Lucia
Farrera, Alodi
Jaramillo, Claudia
Arias, Williams
Fuentes, Macarena
Everardo, Paola
Avila, Francisco de
Gómez Valdés, Jorge A.
Hunemeier, Tábita
Gibbon, Sahra
Gallo, Carla
Poletti, Giovanni
Rosique, Javier
Bortolini, Maria Cátira
Canizales-Quinteros, Samuel
Rothhammer, Francisco
Bedoya, Gabriel
Ruiz-Linares, Andres
Gonzáles José, Rolando
Abstract Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuais can be of help to characterize the impact of a genome's heterozygosity on the deveiopmental basis of both fl.uctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and ftuctuating asymmetry (FA), as well as correiations and multipie regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Resuits indicate that directional and FA are both signi:ficant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuais exhibit lower leveis of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare leveis of asymmetries on groups differing on socioeconomic leveis, as a proxy to estimate developmental noise.
Contido em American journal of physical anthropology. Vol. 157, no. 1 (2015), p. 58-70
Assunto América Latina
Ancestralidade
Assimetria facial
[en] Facial directional asymmetry
[en] Facial fluctuating asymmetry
[en] Genetic ancestry
[en] Geometric morphometrics
[en] Latin America
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/122629
Arquivos Descrição Formato
000966103.pdf (10.84Mb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.