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Costs of genetic testing : supporting brazilian public policies for the incorporating of molecular diagnostic technologies

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Costs of genetic testing : supporting brazilian public policies for the incorporating of molecular diagnostic technologies

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Título Costs of genetic testing : supporting brazilian public policies for the incorporating of molecular diagnostic technologies
Autor Schlatter, Rosane Paixão
Matte, Ursula da Silveira
Polanczyk, Carisi Anne
Santos, Patricia Koehler dos
Prolla, Patrícia Ashton
Abstract This study identifies and describes the operating costs associated with the molecular diagnosis of diseases, such as hereditary cancer. To approximate the costs associated with these tests, data informed by Standard Operating Procedures for various techniques was collected from hospital software and a survey of market prices. Costs were established for four scenarios of capacity utilization to represent the possibility of suboptimal use in research laboratories. Cost description was based on a single site. The results show that only one technique was not impacted by rising costs due to underutilized capacity. Several common techniques were considerably more expensive at 30% capacity, including polymerase chain reaction (180%), microsatellite instability analysis (181%), gene rearrangement analysis by multiplex ligation probe amplification (412%), non-labeled sequencing (173%), and quantitation of nucleic acids (169%). These findings should be relevant for the definition of public policies and suggest that investment of public funds in the establishment of centralized diagnostic research centers would reduce costs to the Public Health System.
Contido em Genetics and molecular biology. Ribeirão Preto, SP. Vol. 38, no. 3, (2015), p. 332-337
Assunto Diagnostico molecular
Hereditariedade
Neoplasias
Testes genéticos
[en] Cost analysis
[en] Hereditary cancer
[en] Molecular diagnosis
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/129471
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