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Efeitos do resveratrol nos componentes sinápticos e no comportamento sensorial de busca ao ninho no modelo animal de autismo por exposição pré-natal ao ácido valpróico

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Efeitos do resveratrol nos componentes sinápticos e no comportamento sensorial de busca ao ninho no modelo animal de autismo por exposição pré-natal ao ácido valpróico

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Título Efeitos do resveratrol nos componentes sinápticos e no comportamento sensorial de busca ao ninho no modelo animal de autismo por exposição pré-natal ao ácido valpróico
Autor Silva, Mellanie Fontes Dutra da
Orientador Gottfried, Carmem Juracy Silveira
Co-orientador Bambini Júnior, Victorio
Data 2015
Nível Mestrado
Instituição Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saúde. Programa de Pós-Graduação em Neurociências.
Assunto Ácido valpróico
Comportamento animal
Resveratrol
Sinaptofisina
Tonsila do cerebelo
Transtorno autístico
Resumo Autism spectrum disorder (ASD) is classified as a neurovelopmental disorder, presenting impairments in social communication and sociability, as well as stereotyped behavioral patterns. Although the etiology remains unknown, there is growing evidence suggesting a complex interplay between genetic and environmental risk factors during the gestational period. Many alterations are related to ASD, as multisensory alterations and recent data were pointing out the misbalance between excitation and inhibition, with high predominance in excitation compound, in cortical areas related to sensory processing. The valproic acid (VPA) exposure is an environmental risk to ASD and VPA is commonly used by our group to induce autistic-like behaviors in rodents. We previously showed that a prenatal subchronic treatment of the pregnant rats with resveratrol (RSV) prevented the social deficits induced by VPA in male offspring rats. The present work evaluated the influence of RSV and VPA interaction in the nest seeking behavior in 10 days old male rats and in the relative genic expression levels of synaptic proteins (Sinaptophysin) in excitatory (PSD95) and inhibitory synapses (Gephyrin) in amygdala region of 30 days old rats. We identified impairments in the number of correct choices to the nest in VPA group, which were in accordance to the literature data. Nevertheless, we showed, for the first time, that resveratrol were able to prevent these impairments In RSV+VPA group. Besides, the present work showed important significant alterations at the genic expression level of synaptic proteins related to excitatory and inhibitory synapses in the amygdala region, an important brain structure related to attachment behavior and altered in ASD. Therefore, these data highlights resveratrol as an important molecule for prevention of autistic-like sensory behaviors in the animal model of autism induced by prenatal exposure to VPA, as well as an important tool for seeking etiological targets and physiopathology studies in TEA.
Tipo Dissertação
URI http://hdl.handle.net/10183/129747
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