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ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area

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ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area

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Título ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area
Autor Borghese, Bruno
Chartier, Mélanie
Souza, Carlos Augusto Bastos de
Santulli, Pietro
Pillet, Marie-Christine Lafay
Ziegler, Dominique de
Chapron, Charles
Abstract Objectives.The identification of epidemiological factors increasing the risk of endometriosis could shorten the time to diagnosis. Specific blood groups may be more common in patients with endometriosis. Study Design. We designed a cross-sectional study of 633 Caucasian women living in the same geographic area. Study group included 311 patients with histologically proven endometriosis. Control group included 322 patients without endometriosis as checked during surgery. Frequencies of ABO and Rhesus groups in the study and control groups were compared using univariate and multivariate analyses. Results. We observed a higher proportion of Rh-negativewomen in the study group, as compared to healthy controls.Multivariate analysis showed that Rhnegative women are twice as likely to develop endometriosis (aOR = 1.90; 95% CI: 1.20–2.90). There was no significant difference in ABO group distribution between patients and controls. There was no difference when taking into account either the clinical forms (superficial endometriosis, endometrioma, and deep infiltration endometriosis) or the rAFS stages. Conclusion. Rh-negative women are twice as likely to develop endometriosis. Chromosome 1p, which contains the genes coding for the Rhesus, could also harbor endometriosis susceptibility genes.
Contido em BioMed Research International. New York, NY. Vol. 2014 (2014), ID 618964, [6] p.
Assunto Endometriose
Predisposição genética para doença
Sistema do grupo sanguíneo ABO
Sistema do grupo sanguíneo Rh-Hr
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/129821
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