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Related factors to atazanavir plasma levels in a cohort of HIV positive individuals with undetectable viral load

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Related factors to atazanavir plasma levels in a cohort of HIV positive individuals with undetectable viral load

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Título Related factors to atazanavir plasma levels in a cohort of HIV positive individuals with undetectable viral load
Autor Sprinz, Eduardo
Luz, Ana Júlia Bretanha
Weyh, Julia Poeta
Linden, Rafael
Antunes, Marina Venzon
Caminha, Luiza Isola
Abstract To evaluate the factors associated with plasma concentrations of atazanavir (ATV) in a cohort of well-controlled HIV infected subjects (undetectable viremia). Design: Cross-sectional study where 69 subjects were consecutively enrolled between April and November, 2011. Methods: Patients had to be on atazanavir for at least six months, undetectable viral load for a period equal to or longer than 12 months, T CD4+ lymphocyte count higher than 200 cells/mm3, and aged between 18 years and 70 years old. Exclusion criteria were pregnancy, any neurologic disease, active opportunistic disease, hepatitis or cancer. Atazanavir plasma levels were measured by ultra-performance liquid chromatography. Results and discussion: Overall, 54 patients (mean age of 47 years and 50% women) were included in the analysis. Those without ritonavir (unboosted atazanavir) had statistically lower plasma concentrations than those with ritonavir boosted atazanavir (p = 0.001) and total and indirect bilirubin were statistically associated with plasma concentration of atazanavir (r = 0.32 and r = 0.33 respectively; p < 0.05 in both cases). No statistical association was found among gender, ethnicity, age, weight, body mass index (BMI), lipid profile, and the plasma concentration of atazanavir. Conclusion: In summary, as expected, concomitant ritonavir use was the only factor associated with atazanavir plasma levels. Prospective studies with a larger sample size might help to observe an association of atazanavir concentrations to other characteristics such as body weight, since the p-value showed to be close to significance (p = 0.068).
Contido em Brazilian journal of infectious diseases. Salvador. Vol. 17, n. 6 (nov./dez. 2013), p. 657–660
Assunto Antirretrovirais
HIV
Inibidores da protease HIV
Ritonavir
[en] Atazanavir
[en] Drug concentration
[en] Lipid profile
[en] Plasma levels
[en] Ritonavir
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/131154
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