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Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D

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Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D

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Título Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D
Autor Swat, Maciej
Thomas, Gilberto Lima
Shirinifard, Abbas
Clendenon, Sherry G.
Glazier, James Alexander
Abstract Tumor cells and structure both evolve due to heritable variation of cell behaviors and selection over periods of weeks to years (somatic evolution). Micro-environmental factors exert selection pressures on tumor-cell behaviors, which influence both the rate and direction of evolution of specific behaviors, especially the development of tumor-cell aggression and resistance to chemotherapies. In this paper, we present, step-by-step, the development of a multi-cell, virtual-tissue model of tumor somatic evolution, simulated using the open-source CompuCell3D modeling environment. Our model includes essential cell behaviors, microenvironmental components and their interactions. Our model provides a platform for exploring selection pressures leading to the evolution of tumor-cell aggression, showing that emergent stratification into regions with different cell survival rates drives the evolution of less cohesive cells with lower levels of cadherins and higher levels of integrins. Such reduced cohesivity is a key hallmark in the progression of many types of solid tumors.
Contido em PLoS ONE. San Francisco. Vol. 10, no. 6 (June 2015), e0127972, 40 p.
Assunto Biofisica celular
Dinamica celular
Simulação computacional
Tensao superficial
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/131377
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