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dc.contributor.authorSantetti, Danielept_BR
dc.contributor.authorWilasco, Maria Inês de Albuquerquept_BR
dc.contributor.authorDornelles, Cristina Toscani Lealpt_BR
dc.contributor.authorWerlang, Isabel Cristina Ribaspt_BR
dc.contributor.authorFontella, Fernanda Urruthpt_BR
dc.contributor.authorKieling, Carlos Oscarpt_BR
dc.contributor.authorSantos, Jorge Luiz dospt_BR
dc.contributor.authorVieira, Sandra Maria Gonçalvespt_BR
dc.contributor.authorGoldani, Helena Ayako Suenopt_BR
dc.date.accessioned2016-01-20T02:39:33Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn2219-2840pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/131984pt_BR
dc.description.abstractAIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease. METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease (MELD) and Pediatric End Stage Liver Disease (PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition (Z-score < -1.00) and malnutrition (Z-score < -2.00). Interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status RESULTS: The median (25th-75th centile) age of the study population was 60 (17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease (72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk (34.9%) compared with those who were well-nourished [7.12 (0.58-34.23) pg/mL vs 1.63 (0.53-3.43) pg/mL; P = 0.02], correlating inversely with triceps skinfold-for-age z-score (rs = -0.61; P < 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score (P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofWorld journal of gastroenterology. Beijing. Vol. 21, no. 29 (Aug. 7, 2015), p. 8927-8934pt_BR
dc.rightsOpen Accessen
dc.subjectCytokinesen
dc.subjectCitocinaspt_BR
dc.subjectInterleucina-6pt_BR
dc.subjectInterleukin-6en
dc.subjectMalnutritionen
dc.subjectDesnutriçãopt_BR
dc.subjectFibrosept_BR
dc.subjectCirrhosisen
dc.subjectCriançapt_BR
dc.subjectChilden
dc.titleSerum proinflammatory cytokines and nutritional status in pediatric chronic liver diseasept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000978823pt_BR
dc.type.originEstrangeiropt_BR


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