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Alkaloids in erythrina by UPLC-ESI-MS and in vivo hypotensive potential of extractive preparations

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Alkaloids in erythrina by UPLC-ESI-MS and in vivo hypotensive potential of extractive preparations

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Título Alkaloids in erythrina by UPLC-ESI-MS and in vivo hypotensive potential of extractive preparations
Autor Mergulo, Liara
Santos, Marí Castro
Sant'Anna, Liane Santariano
Cordeiro, Everson Willian Fialho
Mendez, Andreas Sebastian Loureiro
Moreira, Cleci Menezes
Garcia, Cassia Virginia
Miotto, Silvia Teresinha Sfoggia
Batista, Luiz Alcides das Chagas
Abstract Erythrina species are used in popular medicine as sedative, anxiolytic, anti-inflammatory, and antihypertensive. In this work, we investigated the chemical composition of extracts obtained from leaves of E. falcata and E. crista-galli. The hypotensive potential of E. falcata and the mechanism of action were also studied. The extracts were obtained by maceration and infusion. The total content of phenolic compounds and flavonoids was estimated by spectrophotometric methods. The chemical constituents were studied performing a chromatographic analysis by UPLC-ESI-MS. For in vivo protocols, blood pressure and heart rate were measured by the invasive hemodynamic monitoring method. Different concentrations of extracts and drugs such as L-NAME, losartan, hexamethonium, and propranolol were administrated i.v.The results of total phenolic contents for E. falcata and E. cristagalli were 1.3193–1.4989mgGAE/mL for maceration and 0.8771–0.9506mgGAE/mL for infusion. In total flavonoids, the content was 7.7829–8.1976mg RE/g for maceration and 9.3471–10.4765 REmg/g for infusion. The chemical composition was based on alkaloids, suggesting the presence of erythristemine, 11𝛽-methoxyglucoerysodine, erysothiopine, 11𝛽-hydroxyerysodine-glucose, and 11-hydroxyerysotinone-rhamnoside. A potent dose-dependent hypotensive effect was observed for E. falcata, which may be related to the route of 𝛽-adrenergic receptors.
Contido em Evidence-based complementary and alternative medicine : eCAM. [New York]. Vol. 2015, (2015), ID 959081, 12 p.
Assunto Alcalóides
Farmácia
Química
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/131988
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