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Antiherpes activity and skin/mucosa distribution of flavonoids from achyrocline satureioides extract incorporated into topical nanoemulsions

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Antiherpes activity and skin/mucosa distribution of flavonoids from achyrocline satureioides extract incorporated into topical nanoemulsions

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Título Antiherpes activity and skin/mucosa distribution of flavonoids from achyrocline satureioides extract incorporated into topical nanoemulsions
Autor Bidone, Juliana
Argenta, Débora Fretes
Kratz, Jadel Muller
Pettenuzzo, Letícia Ferreira
Horn, Ana Paula
Koester, Leticia Scherer
Bassani, Valquiria Linck
Simões, C.M.O
Teixeira, Helder Ferreira
Abstract This study investigated the inhibitory effects of Achyrocline satureioides extract (ASE) incorporated into a topical nanoemulsion on Herpes Simplex Virus type 1 (HSV-1/KOS strain) replication, as well as the distribution of the main ASE flavonoids (quercetin, luteolin, and 3-O-methylquercetin) in porcine skin and mucosa.The ASE-loaded nanoemulsion showed more pronounced effects against HSV-1 replication when compared to the ASE or pure quercetin, as determined by the viral plaque number reduction assay. All flavonoids were detected in the skin epidermis (2.2 𝜇g/cm2) and the mucosa upper layers (3.0𝜇g/cm2) from ASE-loaded nanoemulsion until 8 h after topical application. A higher amount of flavonoids was detected when these tissues were impaired, especially in deeper mucosa layers (up to 7-fold). Flavonoids were detected in the receptor fluid only when the mucosa was injured. Such results were supported by confocal microscopy images. Overall, these findings suggest that the tested ASE-loaded nanoemulsion has potential to be used topically for herpes infections.
Contido em BioMed Research International. New York. Vol. 2015, p. 1-7
Assunto Achyrocline satureioides
Farmacologia
Flavonoides
Herpes simplex
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/132019
Arquivos Descrição Formato
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