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Evaluation of toxic metals and essential elements in children with learning disabilities from a rural area of southern Brazil

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Evaluation of toxic metals and essential elements in children with learning disabilities from a rural area of southern Brazil

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Título Evaluation of toxic metals and essential elements in children with learning disabilities from a rural area of southern Brazil
Autor Nascimento, Sabrina Nunes do
Charão, Mariele Feiffer
Moro, Angela Maria
Roehrs, Miguel
Paniz, Clóvis
Baierle, Marília
Brucker, Natália
Gioda, Adriana
Barbosa Júnior, Fernando
Bohrer, Denise
Ávila, Daiana Silva de
Garcia, Solange Cristina
Abstract Children’s exposure to metals can result in adverse effects such as cognitive function impairments. This study aimed to evaluate some toxic metals and levels of essential trace elements in blood, hair, and drinking water in children from a rural area of Southern Brazil. Cognitive ability and δ-aminolevulinate dehydratase (ALA-D) activity were evaluated. Oxidative stress was evaluated as a main mechanism of metal toxicity, through the quantification of malondialdehyde (MDA) levels. This study included 20 children from a rural area and 20 children from an urban area. Our findings demonstrated increase in blood lead (Pb) levels (BLLs). Also, increased levels of nickel (Ni) in blood and increase of aluminum (Al) levels in hair and drinking water in rural children were found. Deficiency in selenium (Se) levels was observed in rural children as well. Rural children with visual-motor immaturity presented Pb levels in hair significantly increased in relation to rural children without visual-motor immaturity (p < 0.05). Negative correlations between BLLs and ALA-D activity and positive correlations between BLLs and ALA-RE activity were observed. MDA was significantly higher in rural compared to urban children (p < 0.05). Our findings suggest that rural children were co-exposed to toxic metals, especially Al, Pb and Ni. Moreover, a slight deficiency of Se was observed. Low performance on cognitive ability tests and ALA-D inhibition can be related to metal exposure in rural children. Oxidative stress was suggested as a main toxicological mechanism involved in metal exposure.
Contido em International Journal of Environmental Research and Public Health. Basel. Vol. 11, n. 10 (2014), p. 10806-10823
Assunto Farmácia
[en] ALA-D inhibition
[en] Cognitive ability
[en] Essential and toxic elements
[en] Oxidative stress
[en] Rural children
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/140234
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