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Aggressive fluid and sodium restriction in acute decompensated heart failure : a randomized clinical trial

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Aggressive fluid and sodium restriction in acute decompensated heart failure : a randomized clinical trial

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Título Aggressive fluid and sodium restriction in acute decompensated heart failure : a randomized clinical trial
Autor Aliti, Graziella Badin
Silva, Eneida Rejane Rabelo da
Clausell, Nadine Oliveira
Rohde, Luis Eduardo Paim
Biolo, Andreia
Silva, Luis Beck da
Abstract Importance: The benefits of fluid and sodium restriction in patients hospitalized with acute decompensated heart failure (ADHF) are unclear. Objective: To compare the effects of a fluid-restricted (maximum fluid intake, 800 mL/d) and sodiumrestricted (maximum dietary intake, 800 mg/d) diet (intervention group [IG]) vs a diet with no such restrictions (control group [CG]) on weight loss and clinical stability during a 3-day period in patients hospitalized with ADHF. Design: Randomized, parallel-group clinical trial with blinded outcome assessments. Setting: Emergency room, wards, and intensive care unit. Participants: Adult inpatients with ADHF, systolic dysfunction, and a length of stay of 36 hours or less. Intervention: Fluid restriction (maximum fluid intake, 800 mL/d) and additional sodium restriction (maximum dietary intake, 800 mg/d) were carried out until the seventh hospital day or, in patients whose length of stay was less than 7 days, until discharge. The CG received a standard hospital diet, with liberal fluid and sodium intake. Main Outcomes and Measures: Weight loss and clinical stability at 3-day assessment, daily perception of thirst, and readmissions within 30 days. Results: Seventy-five patients were enrolled (IG, 38; CG, 37). Most weremale; ischemic heart disease was the predominant cause of heart failure (17 patients [23%]), and the mean (SD) left ventricular ejection fraction was 26% (8.7%). The groups were homogeneous in terms of baseline characteristics. Weight loss was similar in both groups (between-group difference in variation of 0.25 kg [95% CI, 1.95 to 2.45]; P=.82) as well as change in clinical congestion score (between-group difference in variation of 0.59 points [95% CI, 2.21 to 1.03]; P=.47) at 3 days. Thirst was significantly worse in the IG (5.1[2.9]) than the CG (3.44[2.0]) at the end of the study period (between-group difference, 1.66 points; time group interaction; P=.01). There were no significant betweengroup differences in the readmission rate at 30 days (IG, 11 patients [29%]; CG, 7 patients [19%]; P=.41). Conclusions and Relevance: Aggressive fluid and sodium restriction has no effect on weight loss or clinical stability at 3 days and is associated with a significant increase in perceived thirst.Weconclude that sodium and water restriction in patients admitted for ADHF are unnecessary.
Contido em JAMA: Internal Medicine. Chicago. Vol. 173, no. 12 (June 2013), p. 1058-1064
Assunto Insuficiência cardíaca
Sódio na dieta
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/142362
Arquivos Descrição Formato
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