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Efficaccy of celecoxib in treating symptoms of viral pharyngitis : a double-blind, randomized study of celecoxib versus diclofenac

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Efficaccy of celecoxib in treating symptoms of viral pharyngitis : a double-blind, randomized study of celecoxib versus diclofenac

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Título Efficaccy of celecoxib in treating symptoms of viral pharyngitis : a double-blind, randomized study of celecoxib versus diclofenac
Autor Weckx, Luc Louis Maurice
Ruiz, Jorge Eliecer
Duperly, J.
Martínez Mendizabal, G. A.
Rausis, M. B. G.
Piltcher, Simao Levin
Saffer, Moacyr
Matsuyama, C.
Levy, S.
Fort, J. G.
Abstract This study compared the efficacy and safety of the cyclooxygenase-2 specific inhibitor celecoxib with the conventional nonsteroidal anti-inflammatory drug diclofenac in the symptomatic treatment of viral pharyngitis. Adult patients from 27 study centers in Latin America were treated with oral doses of celecoxib 200 mg once daily or 200 mg twice daily, or diclofenac 75 mg twice daily for 5 days in a double-blind, randomized study. The primary efficacy assessment was ‘Throat Pain on Swallowing’ on day 3. In addition, secondary quality-of-life assessments were performed on days 3 and 5. All adverse events and treatment-emergent signs and symptoms were recorded. Data from 313 patients were evaluable for efficacy (105 celecoxib 200 mg once daily, 107 celecoxib 200 mg twice daily, 101 diclofenac 75 mg twice daily). The upper 95% confidence limits for the visual analog scale of ‘Throat Pain on Swallowing’ on day 3 for celecoxib 200 mg once daily relative to diclofenac 75 mg twice daily, and celecoxib 200 mg twice daily relative to diclofenac 75 mg twice daily were 9.26 and 7.83, respectively. All secondary efficacy and quality-of-life measures were clinically similar for the three treatment groups, and no statistically significant differences were detected The incidences of treatmentemergent adverse events and withdrawals due to adverse events were similar for all groups, but numerically higher among patients taking diclofenac than celecoxib. More patients in the diclofenac group reported gastrointestinal complaints (7.3%) compared with those in the celecoxib groups (4.3% in the celecoxib 200 mg once-daily group and 3.4% in the celecoxib 200 mg twice-daily group). In conclusion, 5 days of treatment with celecoxib 200 mg once daily is as effective as diclofenac 75 mg twice daily in the symptomatic treatment of viral pharyngitis. Celecoxib 200 mg once daily is also as effective as celecoxib 200 mg twice daily in this condition.
Contido em Journal of international medical research. Northampton. Vol. 30, no. 2 (Mar./Apr. 2002), p. 185-194
Assunto Aerofagia
Faringite
Quimioterapia
[en] Celecoxib
[en] Cyclooxygenase (COX)-2 specific inhibitors
[en] Symptomatic treatment
[en] Throat pain on swallowing
[en] Viral pharyngitis
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/143530
Arquivos Descrição Formato
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