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Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration

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Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration

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Título Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration
Autor Gomes, Sabrina Carvalho
Abascal, C.C.
Haas, Alex Nogueira
Angst, Patrícia Daniela Melchiors
Oppermann, Rui Vicente
Marcantonio, Rosemary Adriana Chierici
Abstract T his i nvestigation c ompared g ingival c revicular fl uid (GCF) interleukin-1β (IL-1β) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 ± 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingival control with weekly recall visits. Periodontal probing depth (PPD), bleeding on probing (BOP) and GCF samples (from different PPD category sites: 3-5 mm and 6–10 mm) were obtained at the baseline, 30, and 180 days. IL-1β was assessed by enzyme-linked immunosorbent assay. Generalized estimating equations were used to fit prediction models of IL-1β changes, considering the dependence between the examinations, and using only data from experimental sites. Overall IL-1β concentrations decreased from 3.2 pg/μL to 1.9 pg/μL. Higher baseline IL-1β concentrations were associated with higher baseline PPD values in both groups. There were no differences in IL-1β concentrations between never-smokers and smokers over time for any PPD category. Higher baseline PPD values and the presence of BOP on day 180 were significantly associated with higher IL-1β concentrations. A strict Supra regimen reduced IL-1β concentrations over time in periodontitis patients. The benefits observed for smokers underline the importance of oral hygiene measures, even considering the presence of this important risk factor.
Contido em Brazilian oral research. São Paulo. Vol. 29, no. 1 (2015), p. 1-8
Assunto Biofilmes
Hábito de fumar
Periodontia : Doencas
Placa dentaria
[en] Dental plaque
[en] Interleukin-1Beta
[en] Periodontal disease
[en] Smoking
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/147077
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