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Cranial vault reconstruction with bone morphogenetic protein, calcium phosphate, acellular dermal matrix, and calcium alginate in mice

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Cranial vault reconstruction with bone morphogenetic protein, calcium phosphate, acellular dermal matrix, and calcium alginate in mice

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Título Cranial vault reconstruction with bone morphogenetic protein, calcium phosphate, acellular dermal matrix, and calcium alginate in mice
Autor Portinho, Ciro Paz
Santos, Luis Alberto dos
Cerski, Carlos Thadeu Schmidt
Rivero, Raquel Camara
Collares, Marcus Vinicius Martins
Abstract ABSTRACTPURPOSE: To evaluate experimental cranial vault reconstructions, by combining bone morphogenetic protein type 2 (BMP-2) and different matrices.METHODS: Fourty-nine animals were initially included (seven per group). We designed an experimental, open, prospective and comparative study, divided in seven groups: 1 – BMP-2+calcium phosphate (BT); 2 – BMP-2+acellular dermal matrix (BM); 3 – BMP-2+calcium alginate (BA); 4 – TCP; 5 – MDM; 6 – ALG; 7 – Bone autograft (BAG). A bone failure was created in left parietal bone of adult male mice. At the same procedure reconstruction was performed. After five weeks, animals were sacrificed, and reconstruction area was removed to histological analysis. After exclusion due to death or infection, thirty-eight animals were evaluated (BT=5; BM=6; BA=6; TCP=7; MDM=3; ALG=6; BAG=5).RESULTS: A higher incidence of infection has occurred in MDM group (57%, P=0.037). In cortical fusion, groups BAG, TCP, and BMP-2+TCP (BT) obtained the best scores, comparing to the others (P=0.00846). In new bone formation, groups BT, BAG, and TCP have presented the best scores (P=0.00835). When neovascularization was considered, best groups were BMP-2+MDM (BM), BMP-2+ALG (BA), TCP, and MDM (P=0.001695). BAG group was the best in bone marrow formation, followed by groups BT and TCP (P=0.008317). CONCLUSIONS: Bone morphogenetic protein type 2 increased bone regeneration in experimental skull reconstruction, especially when combined to calcium phosphate. Such association was even comparable to bone autograft, the gold-standard treatment, in some histological criteria.
Contido em Acta cirúrgica brasileira. São Paulo, SP. Vol. 29, no. 10 (Oct. 2014), p. 622-632
Assunto Engenharia de tecidos
Osso e ossos
[en] Bone and bones
[en] Bone matrix
[en] Bone transplantation
[en] Craniofacial abnormalities
[en] Mice
[en] Tissue engineering
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/147197
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